加味导赤散联合沙利度胺片治疗心脾积热型复发性阿弗他溃疡的疗效评价

Evaluation of the Therapeutic Effect of Modified Daochi Powder Combined with Thalidomide Tablets in the Treatment of Recurrent Aphthous Ulcers of Heart Spleen Heat Type

目的:研究加味导赤散联合沙利度胺片治疗心脾积热型复发性阿弗他溃疡的疗效。方法:在本文研究将2022年1月—2023年6月上海中医药大学附属普陀医院收治的88例心脾积热型复发性阿弗他溃疡患者作为研究主要对象,随机分组为两组,各44例,对照组实施沙利度胺片治疗,观察组实施加味导赤散联合沙利度胺片治疗,分析并对比两组发作间歇时间、总有效率、溃疡复发率、炎症因子水平。结果:观察组发作间歇时间优于对照组,差异有统计学意义(P<0.05);观察组治疗4周的总有效率高于对照组,差异有统计学意义(P<0.05);观察组溃疡复发率低于对照组,差异有统计学意义(P<0.05);观察组治疗后炎症因子低于对照组,差异有统计学意义(P<0.05)。结论:通过对心脾积热型复发性阿弗他溃疡患者开展联合治疗(加味导赤散、沙利度胺片),能显著提高疗效。

Objective:To investigate the efficacy of Modified Daochi Powder combined with Thalidomide Tablets in the treatment of recurrent aphthous ulcers of heart spleen heat type.Method:In this study,88 patients with heart spleen heat type recurrent aphthous ulcers admitted to Shanghai University of Traditional Chinese Medicine Affiliated Putuo Hospital from January 2022 to June 2023 were selected as the main research subjects.They were randomly divided into two groups,44 patients in each group,with the control group received treatment with Thalidomide Tablets and the observation group received treatment with Modified Daochi Powder combined with Thalidomide Tablets.The interval time between attacks,total effective rate,ulcer recurrence rate,and inflammatory factor levels were analyzed and compared between the two groups.Result:The interval time between attacks in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group after 4 weeks of treatment was higher than that of the control group,and the difference was statistically significant(P<0.05).The ulcer recurrence rate in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The inflammatory factors in the observation group were lower than those in the control group after treatment,and the difference was statistically significant(P<0.05).Conclusion:Combination therapy(Modified Daochi Powder,Thalidomide Tablets)can significantly improve the efficacy of recurrent aphthous ulcers in patients with heart spleen heat accumulation type.