针灸促进脊髓损伤后细胞增殖和分化的研究进展

Research Progress of Acupuncture Promoting Cell Proliferation and Differentiation after SCI

脊髓损伤后神经缺损的有效修复仍然是临床治疗的挑战。随着干细胞和再生医学的发展,目前常用的脊髓损伤细胞治疗包括促进内源性干细胞分化、神经干细胞、嗅鞘细胞以及雪旺细胞等移植治疗。然而,不同细胞来源的干细胞均存在各自的局限性,而联合应用针灸治疗能够直接调控内源性神经干细胞的增殖和分化、促进外源性移植细胞的存活和向损伤局部的迁移、促进轴突再生以及修复脊髓继发性损伤的微环境。在后续研究中应围绕参数标准化、再生精准化和方案制度化,推动针灸联合细胞移植方法在脊髓损伤诊疗方案中的应用。

The effective repair of neural deficits following spinal cord injury(SCI)remains a clinical challenge.With the advancement of stem cells and regenerative medicine,current cell therapies for SCI include promoting endogenous stem cells differentiation and transplanting neural stem cells,olfactory ensheathing cells and Schwann cells.However,each source of stem cells has its own limitations.Combining acupuncture and moxibustion therapy can directly regulate the proliferation and differentiation of endogenous neural stem cells,enhance the survival and migration of exogenous transplanted cells to the injury site,promote axon regeneration,and repair the microenvironment of secondary SCI.Future research should focus on standardizing parameters,precision in regeneration,and systematizing treatment protocols to promote the application and dissemination of acupuncture and moxibustion combined with cell transplantation methods in the therapeutic strategies for SCI.