耐碳青霉烯类肠杆菌耐药机制的研究进展

Research progress on resistance mechanisms of carbapenem-resistant Enterobacteriaceae

耐碳青霉烯类肠杆菌(CRE)是全球范围内日益严重的人类健康威胁。CRE通常携带多种耐药基因,限制了治疗药物选择,需要更长的治疗时间,治疗费用更高且治疗风险更大。该综述概述了CRE的流行病学、耐药机制、耐药现状以及最新治疗药物的介绍。为临床合理使用抗菌药物,耐药菌感染的防控和治疗提供依据。

Carbapenem-resistant Enterobacteriaceae(CRE)is an increasingly serious threat to human health worldwide.CRE usually carries multiple drug resistance genes,which limit the selection of therapeutic drugs,prolong treatment time,require higher treatment costs and greater treatment risks.The epidemiology,resistance mechanisms,current resistance status of CRE and the latest therapeutic drugs for CRE were summarized in this papoer,which provide a basis for the rational use of antibiotics in clinical prevention and treatment of drug-resistant bacterial infections.