难治性强迫症脑深部电刺激疗法中国专家共识

Chinese experts consensus on deep brain stimulation therapy for refractory obsessive-compulsive disorder

强迫症(OCD)是一种慢性且高度致残的精神障碍,终身患病率较高,严重影响患者的生活质量,并对家庭和社会造成巨大负担。尽管经过充分的药物和心理治疗,仍有约10%~20%的患者疗效不佳,被定义为难治性强迫症。脑深部电刺激(DBS)作为一种微创、可逆、可调的神经调控技术,已被多个国外监管机构批准用于治疗难治性强迫症,并被多项学术指南和共识推荐。目前,国内多家医疗中心已经开展难治性强迫症的DBS手术治疗,但尚缺乏统一的相关诊疗规范。为此,功能神经外科和精神科领域的专家,结合临床经验和国内外研究成果,经过充分讨论,制定了本共识,旨在规范DBS疗法的标准化流程,确保其在临床应用中的科学性、安全性和有效性。

Obsessive-compulsive disorder(OCD)is a chronic and highly disabling psychiatric disorder with a significant lifetime prevalence.It severely impacts the quality of patients life and imposes a substantial burden on families and society.Despite adequate pharmacological and psychological treatment,10%-20%of patients show insufficient therapeutic response and are classified as refractory OCD.Deep brain stimulation(DBS),a minimally invasive,reversible,and adjustable neuromodulation technique,has been approved by several international regulatory agencies for the treatment of refractory OCD and has been recommended in several clinical guidelines and expert consensus.Currently,multiple medical centers in China have performed DBS surgery for refractory OCD.However,there remains a lack of unified guidelines or standards for clinical practice.Therefore,experts from the fields of functional neurosurgery and psychiatry,based on their clinical experience and both domestic and international research,have jointly formulated this consensus.The aim is to standardize the procedures for DBS therapy,ensuring its scientific,safe,and effective application in clinical settings.