创伤后癫痫生物标志物研究进展

Research progress on biomarkers for post-traumatic epilepsy

生物标志物是指可以作为正常生理过程、病理过程或对反应指标进行客观测量的指标,具有非常广泛的用途,如疾病诊断、判断疾病分期、评价新药或新疗法的安全性与有效性等。创伤后癫痫(PTE)作为创伤性颅脑损伤(TBI)后最为严重的并发症已经严重影响到国民健康,理应得到所有人的重视。本文总结的PTE生物标志物包括血浆/血清和脑脊液分子生物标志物、影像学生物标志物和电生理生物标志物,以期更加完善关于PTE的科学研究,并为其客观评定提供思路。

Biomarkers are indicators that can be used as objective measures of normal physiological processes,pathological processes,or indicators of response,and have a very wide range of uses,such as diagnosis,disease staging,evaluation of the safety and efficacy of new drugs or treatments and so on.Post-traumatic epilepsy(PTE),as the most serious complication after traumatic brain injury(TBI),has seriously affected human health and deserves everyone s attention.The PTE biomarkers summarized in this paper include plasma/serum and cerebrospinal fluid molecular biomarkers,imaging biomarkers and electrophysiological biomarkers,in order to improve the scientific research on PTE and provide ideas for its objective evaluation.