A型肉毒毒素注射治疗痉挛性斜颈的引导技术研究进展

Research progress on guidance technology for botulinum toxin A injection in the treatment of cervical dystonia

痉挛性斜颈(CD)是临床常见的一种局灶性肌张力障碍疾病,主要由于颈部肌肉不自主收缩引起的异常姿势或运动,大多数为特发性。CD的治疗方法有口服药物、A型肉毒毒素(BoNT-A)注射、手术等方法。BoNT-A注射起效快、持续时间长、副作用小、重复性好,是目前首选的治疗方法。然而不同研究中BoNT-A注射的疗效差异较大,为提高BoNT-A注射疗效,临床上各类引导技术应运而生,本文就各类BoNT-A注射引导技术的优势和不足进行综述。

Cervical dystonia(CD)is a common focal dystonia in clinical practice,which is mainly caused by involuntary contraction of neck muscles,manifesting abnormal posture or movement.Most of them are idiopathic.The treatment of CD includes oral medication,botulinum toxin A(BoNT-A)injection,surgery and so on.BoNT-A injection has rapid onset,long duration,few side effects,and good repeatability,which is currently the preferred treatment.However,the efficacy of BoNT-A injection varies greatly among different studies.In order to improve the efficacy of BoNT-A injection,various clinical guidance techniques have been developed.This article reviews the advantages and disadvantages of various BoNT-A injection guidance techniques.