比较不同通量透析器对尿毒症的治疗效果

Comparing the therapeutic effects of different flux dialyzers on uremia

目的:比较17M低通量透析器与18UC高通量透析器治疗对尿毒症的疗效及对钙磷代谢、生存质量的影响。方法:选取2018年9月至2021年3月本院收治的108例需实施血液透析的尿毒症患者,随机分为低通量组与高通量组,每组57例。比较两组肾功能、钙磷代谢及iPTH水平,并比较临床疗效及生存质量。结果:治疗后,高通量组的BUN、Scr、β2-MG、iPTH、P水平低于低通量组(P<0.05);高通量组患者的治疗总有效率高于低通量组(P<0.05);高通量组治疗后的SF-36总分、肾病和透析相关生存质量总分、总体健康评估评分高于低通量组(P<0.05),结论:采用高通量透析器对尿毒症能够改善临床疗效、肾功能、钙磷代谢、iPTH以及生存质量。

Objective:To compare the efficacy of 17M low flux dialyzer and 18UC high-throughput dialyzer in the treatment of uremia,as well as their impact on calcium and phosphorus metabolism and quality of life.Method:108 uremic patients who underwent hemodialysis and were admitted to our hospital from September 2018 to March 2021 were randomly divided into a low flux group and a high flux group,with 57 cases in each group.Compare renal function,calcium and phosphorus metabolism,and iPTH levels between two groups,and compare clinical efficacy and quality of life.Result:After treatment,the BUN,Scr,andβThe levels of 2-MG,iPTH,and P were lower than those of the low flux group(P<0.05);The total effective rate of treatment in the high-throughput group was higher than that in the low-throughput group(P<0.05);The total score of SF-36,total score of kidney disease and dialysis related quality of life,and overall health assessment score in the high-throughput group were higher than those in the low throughput group after treatment(P<0.05).Conclusion:The use of high-throughput dialyzers can improve clinical efficacy,renal function,calcium and phosphorus metabolism,iPTH,and quality of life in uremia.