基于数据挖掘探析中医药治疗多囊卵巢综合征的用药规律

Medication rule of traditional Chinese medicine in treatment of polycystic ovary syndrome:A study based on data mining

目的:基于数据挖掘探析中医药治疗多囊卵巢综合征(PCOS)的用药规律。方法:检索中国知网、万方数据、维普中文科技期刊数据库自建库至2023年2月28日收录的中医药治疗PCOS的文献,筛选后建立数据库,利用中医传承辅助平台(V3.0)分析PCOS的中医证候,高频药物,药物组合,聚类及其经后期、经间期、经前期、行经期的常用中药,核心组合。结果:涉及中医证候53个,痰湿证排第一位。处方919首,中药313味,前5位为当归、菟丝子、茯苓、熟地黄、香附。中药类别以补虚药、活血化瘀药、理气药为主。获得常用药物组合10组,关联药物组合15组,核心药物组合3组。其中经后期处方118首,中药147味,前5位为菟丝子、熟地黄、当归、茯苓、山茱萸;核心药物组合3组。经间期处方102首,中药153味,前5位为当归、菟丝子、茯苓、熟地黄、丹参;核心药物组合3组。经前期处方104首,中药149味,前5位为菟丝子、当归、茯苓、香附、熟地黄;核心药物组合3组。行经期处方73首,中药128味,前5位为当归、香附、益母草、茯苓、丹参;核心药物组合3组。结论:中医药治疗PCOS突出补肾养精,同时重视活血化瘀、理气化痰祛湿。经后期以补肾精为主,方用左归饮、养精种玉汤;经间期补肾、活血化瘀并重,方用六味地黄丸合四物汤;经前期重在补肾阳,依健脾理气法、补肾助阳法处方;行经期着重理气活血,方用四物汤。

Objective:To investigate the medication rule of traditional Chinese medicine(TCM) in the treatment of polycystic ovary syndrome(PCOS) based on data mining.Methods:CNKI,Wanfang Data,and VIP were searched for articles on TCM treatment of PCOS published up to February 28,2023,and a database was established after screening.Traditional Chinese Medicine Inheritance Support System(V3.0) was used to analyze the TCM syndromes of PCOS,high-frequency drugs,drug combinations,clusters,and commonly used TCM drugs and core drug combinations during the postmenstrual period,the intermenstrual period,the premenstrual period,and the menstrual period.Results:PCOS was associated with 53 TCM syndromes,with phlegm-dampness syndrome as the most common syndrome.A total of 919 prescriptions were obtained,involving 313 TCM drugs,among which the top 5 drugs were Angelica sinensis,China dodder seed,Poria cocos,prepared Radix Rehmanniae,and Rhizoma Cyperi.The TCM drugs used were mainly deficiency-tonifying drugs,blood-activating and stasis-resolving drugs,and Qi-regulating drugs.The analysis obtained 10 commonly used drug combinations,15 associated drug combinations,and 3 core drug combinations.There were 118 prescriptions used during the postmenstrual period,involving 147 TCM drugs,among which the top 5 drugs were China dodder seed,prepared Radix Rehmanniae,Angelica sinensis,Poria cocos,and Comus officinalis,and there were 3 core drug combinations.There were 102 prescriptions used during the intermenstrual period,involving 153 TCM drugs,among which the top 5 drugs were Angelica sinensis,China dodder seed,Poria cocos,prepared Radix Rehmanniae,and Salvia miltiorrhiza,and there were 3 core drug combinations.There were 104 prescriptions used during the premenstrual period,involving 149 TCM drugs,among which the top 5 drugs were China dodder seed,Angelica sinensis,Poria cocos,Rhizoma Cyperi,and prepared Radix Rehmanniae,and there were 3 core drug combinations.There were 73 prescriptions used during the premenstrual period,involving 128 TCM drugs,among which the top 5 drugs were Angelica sinensis,Rhizoma Cyperi,Herba Leonuri,Poria cocos,and Salvia miltiorrhiza,and there were 3 core drug combinations.Conclusion:The TMC treatment of PCOS highlights the importance of tonifying the kidney and nourishing essence and emphasizes the methods of activating blood,resolving stasis,regulating Qi,resolving phlegm,and eliminating dampness.Nourishing kidney-essence is the main therapy during the postmenstrual period,and thus Zuogui decoction and Yangjing Zhongyu decoction are used;both kidney-tonifying therapy and blood-activating and stasis-resolving therapy are emphasized during the intermenstrual period,and thus Liuwei Dihuang pills combined with Siwu Decoction are used;tonifying kidney Yang is the focus during the premenstrual period,and prescriptions should be developed based on the methods of strengthening the spleen,regulating Qi,and tonifying the kidney to strengthen Yang;regulating Qi and activating blood are important during the menstrual period,and thus Siwu Decoction is used.