氧化应激与男性生殖健康的研究进展

Research progress on oxidative stress and male reproductive health

全球不孕不育的发生率较高,其中男性因素占30%~50%。氧化应激被认为是导致男性不育的主要病因之一。体内活性氧类物质生成过多和/或抗氧化防御能力不足可导致男性生殖细胞和精子的脂质过氧化、DNA损伤、细胞凋亡增加等病理过程,最终表现为男性生殖问题。本文旨在阐述氧化应激的发生机制、氧化应激在男性生殖中的病理作用、精液中氧化应激标志物及氧化应激相关男性不育的治疗等。

The incidence of infertility is relatively high globally,with the male factors accounting for 30%-50%.Oxidative stress is considered one of the main causes of male infertility.Excessive production of reactive oxygen species and/or inadequate antioxidant defense ability in vivo can lead to pathological processes such as lipid peroxidation,DNA damage,and increased cell apoptosis in male germ cells and sperm,ultimately resulting in male reproductive problems.This article aims to elucidate the mechanism of oxidative stress,the pathological role of oxidative stress in male reproduction,biomarkers of oxidative stress in semen,and treatment for oxidative stress-related male infertility.