LRG1和PCDH20在宫颈癌组织中的表达情况及临床价值

The expression condition and clinical value of leucine richα2-glycoprotein 1 and procalcitonectin 20 in cervical cancer tissue

目的探讨富亮氨酸α2-糖蛋白1(LRG1)和原钙黏蛋白20(PCDH20)在宫颈癌组织中的表达情况及临床价值。方法选取2019年6月至2020年6月内江市第二人民医院收治的68例宫颈癌患者的宫颈活检标本作为宫颈癌组,并选取本院同期68例宫颈良性肿瘤患者的宫颈活检标本作为对照组,收集宫颈癌组相关临床资料。比较两组LRG1和PCDH20表达情况,分析LRG1和PCDH20表达情况与临床病理特征的关系,采用Spearman分析宫颈癌组织中LRG1和PCDH20表达的相关性,采用Kaplan-Meier法分析宫颈癌组织中LRG1和PCDH20表达与患者预后的关系,采用Cox回归分析影响宫颈癌患者预后的不良因素。结果宫颈癌组LRG1阳性表达率高于对照组(P<0.05),宫颈癌组PCDH20阳性表达率低于对照组(P<0.05)。宫颈癌组LRG1和PCDH20表达情况与肿瘤最大径、恶性肿瘤国际临床病理(TNM)分期、是否有淋巴结转移、组织分化程度及浸润深度相关(P<0.05)。宫颈癌组织中LRG1和PCDH20表达情况呈负相关(r=-0.594,P<0.001)。宫颈癌组织中LRG1阳性表达患者3年生存率低于LRG1阴性表达患者(P<0.05),宫颈癌组织中PCDH20阳性表达患者3年生存率高于PCDH20阴性表达患者(P<0.05)。LRG1阳性表达、PCDH20阴性表达、有淋巴结转移、感染人乳头瘤病毒(HPV)、浸润深度为深肌层均为宫颈癌患者死亡的独立危险因素(P<0.05)。结论在宫颈癌组织中LRG1高表达,PCDH20低表达,两者均与患者预后密切相关,可作为预测指标对宫颈癌患者进行预后评估。

Objective To explore the expression condition and clinical significance of leucine richα2-glycoprotein 1(LRG1)and procalcitonectin 20(PCDH20)in cervical cancer tissue.Methods A total of 68 cervical biopsy specimens from patients with cervical cancer admitted to the Second People′s Hospital of Neijiang between June 2019 and June 2020 were selected as the cervical cancer group,and 68 cervical biopsy specimens from patients with benign cervical tumors during the same period were selected as the control group.The clinical data related to the cervical cancer group were collected.The expression condition of LRG1 and PCDH20 were compared between the two groups,and the relationship between LRG1 and PCDH20 expression conditions and clinicopathological features was analyzed.Spearman correlation was applied to analyze the correlation between LRG1 and PCDH20 expression in cervical cancer tissue.Kaplan-Meier method was applied to analyze the correlation between the expression of LRG1 and PCDH20 in cervical cancer tissue and the prognosis of patients.Cox regression was applied to analyze the negative factors that affect the prognosis of cervical cancer patients.Results The positive expression rate of LRG1 in the cervical cancer group was higher than that in the control group(P<0.05),and the positive expression rate of PCDH20 in the cervical cancer group was lower than that in the control group(P<0.05).The expression conditions of LRG1 and PCDH20 in the cervical cancer group were related to the maximum diameter of the tumor,international clinical pathology of malignant tumors tumor node metastasis(TNM)stage,presence of lymph node metastasis,degree of tissue differentiation,and depth of infiltration(P<0.05).A negative correlation existed between the expression conditions of LRG1 and PCDH20 in cervical cancer tissue(r=-0.594,P<0.001).The 3-year survival rate of patients with LRG1 positive expression in cervical cancer tissue was lower than those with LRG1 negative expression(P<0.05).The 3-year survival rate of patients with positive expression of PCDH20 in cervical cancer tissue was higher than those with negative expression of PCDH20(P<0.05).Positive expression of LRG1,negative expression of PCDH20,lymph node metastasis,human papilloma virus(HPV)infection,and deep myometrial infiltration were all independent risk factors for death in cervical cancer patients(P<0.05).Conclusions LRG1 was highly expressed and PCDH20 was lowly expressed in cervical cancer tissues,both of which were closely related to the prognosis of patients and could be used as predictive indicators for prognostic assessment of cervical cancer patients.