糖尿病肾病血液透析患者应用阿卡波糖治疗的价值分析

Value Analysis of Acarbose Treatment in Hemodialysis Patients with Dia⁃betic Nephropathy

目的 探究糖尿病肾病血液透析患者应用阿卡波糖治疗的效果。方法 回顾性选取2021年4月—2024年4月陆军第七十三集团军医院收治的118例糖尿病肾病血液透析患者的临床资料,按照治疗方法不同将其分为对照组和观察组,各59例。对照组实施胰岛素治疗,观察组实施胰岛素联合阿卡波糖治疗。对比两组患者血糖水平、肾脏功能、胰岛功能。结果 治疗前,两组患者血糖、肾功能指标、胰岛功能指标水平比较,差异无统计学意义(P均>0.05)。治疗后,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白、血尿素氮、血肌酐、尿肌酐、空腹胰岛素、胰岛素抵抗指数水平均低于对照组、胰岛β细胞功能指数高于对照组,差异有统计学意义(P均<0.05)。结论 糖尿病肾病血液透析患者应用胰岛素联合阿卡波糖治疗,可有效改善患者血糖水平、肾脏功能及胰岛功能。

Objective To explore the effect of acarbose in the treatment of hemodialysis patients with diabetic ne-phropathy.Methods The clinical data of 118 hemodialysis patients with diabetic nephropathy admitted to Army 73rd Group Military Hospital from April 2021 to April 2024 were retrospectively selected and divided into control group and observation group according to different treatment methods,with 59 cases in each group.The control group was treated with insulin,and the observation group was treated with insulin combined with acarbose.The blood glucose levels,renal function and islet function were compared between the two groups.Results Before treatment,there were no significant differences in blood glucose,renal function indexes and islet function indexes between the two groups(all P>0.05).After treatment,the levels of fasting blood glucose,2-hour postprandial blood glucose,glycated hemoglo-bin A1c,blood urea nitrogen,serum creatinine,urinary creatinine,fasting insulin and insulin resistance index in the observation group were lower than those in the control group,and the isletβcell function index was higher than that in the control group,the differences were statistically significant(all P<0.05).Conclusion The application of insulin combined with acarbose in hemodialysis patients with diabetic nephropathy can effectively improve the blood glucose level,renal function and islet function.