不同胰岛素用药方式治疗2型糖尿病合并重症呼吸衰竭的疗效及对患者血糖水平的影响

Effect of Different Insulin Administration Methods on Type 2 Diabetes Mellitus Complicated with Severe Respiratory Failure and the Influence on Blood Glucose Level

目的 分析不同胰岛素用药方式治疗2型糖尿病合并重症呼吸衰竭的作用及对患者血糖水平的影响。方法 回顾性选取2023年6月—2024年3月泉州市第一医院城东分院收治的90例糖尿病合并重症呼吸衰竭患者的临床资料,根据治疗方式不同分两组,各45例。两组均实施常规治疗,包括抗氧疗、感染、平喘、化痰等,在糖尿病治疗中,对照组静脉滴注胰岛素,研究组皮下泵入胰岛素,对比两组临床疗效、血糖水平、肺功能及不良反应。结果 研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于对照组,用力肺活量、第一秒用力呼气量、最大通气量均高于对照组,差异有统计学意义(P均<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论 皮下泵入胰岛素治疗2型糖尿病合并重症呼吸衰竭临床疗效较高,能够改善患者血糖水平与肺功能,且不良反应风险较低。

Objective To analyze the effect of different insulin administration on type 2 diabetes mellitus complicated with severe respiratory failure and its influence on blood glucose level.Methods Clinical data of 90 diabetic patients with severe respiratory failure admitted to the Quanzhou First Hospital Chengdong Branch from June 2023 to March 2024 were retrospectively selected,and divided into two groups according to different treatment methods,with 45 cases in each group.Both groups received conventional treatment,including antioxidant therapy,infection,asthmatic relief,phlegm reduction,etc.In diabetes treatment,insulin was injected intravenously in the control group,and insu⁃lin was pumped subcutaneously in the study group.The clinical efficacy,blood glucose level,lung function and ad⁃verse reactions were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of fasting blood glucose,2-hour postprandial blood glucose and glycated hemoglobin A1c in the study group were lower than those in the control group,and the forced vital capacity,forced expiratory volume in the first second and maxi⁃mum ventilation were higher than those in the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Subcutaneous pump insulin for type 2 diabetes combined with severe respiratory failure has high clinical efficacy,improved blood glucose level and lung function,and low risk of adverse effects.