雷珠单抗联合激光治疗糖尿病性黄斑水肿的疗效及对BCVA、CMT的影响

Effect of Leizumab Combined with Laser on BCVA and CMT in Diabetic Macular Edema

目的分析雷珠单抗联合激光治疗糖尿病性黄斑水肿的疗效及对最佳矫正视力(best corrected vision acuity,BCVA)和黄斑中心凹厚度(central macular thickness,CMT)的影响。方法非随机选取莒县中医医院于2022年3月—2023年3月收治的82例糖尿病性黄斑水肿患者为研究对象,根据治疗方法不同分为研究组和对照组,各41例。对照组提供激光治疗,研究组增加雷珠单抗治疗。对比两组临床疗效、视力恢复结果、临床指标及并发症发生情况。结果研究组治疗总有效率为97.56%(40/41),高于对照组的82.93%(34/41),差异有统计学意义(χ^(2)=4.987,P<0.05);治疗后,两组BCVA均明显升高,研究组的BCVA高于对照组,差异有统计学意义(P均<0.05);治疗后研究组CMT、黄斑区视网膜厚度、眼压低于对照组,差异有统计学意义(P均<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论糖尿病性黄斑水肿采取雷珠单抗联合激光治疗,可改善BCVA和CMT,提高临床疗效,且安全性较好。

Objective To analyze the effects of lezumab combined with laser on best corrected vision acuity(BCVA)and central macular thickness(CMT)in the treatment of diabetic macular edema.Methods A total of eighty-two pa-tients with diabetic macular edema admitted to Juxian Hospital of Traditional Chinese Medicine from March 2022 to March 2023 were non-randomly selected as the study objects,and were divided into study group and control group ac-cording to different treatment methods,with forty-one cases in each group.The control group was treated with laser,and the study group was treated with leizumab.The clinical efficacy,visual acuity recovery results,clinical indexes and complications were compared between the two groups.Results The effective rate of the study group was 97.56%(40/41),which was higher than 82.93%(34/41)of the control group,the difference was statistically significant(χ^(2)=4.987,P<0.05).After treatment,BCVA in both groups was increased,and BCVA in the study group was significantly higher than that in the control group,the differences were statistically significant(all P<0.05).After treatment,CMT,macular retinal thickness and IOP in the study group were lower than those in the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion The combination of leizumab and laser therapy for diabetic macular edema can im-prove BCVA and CMT,improve clinical efficacy,and have good safety.