雷贝拉唑三联疗法联合克拉霉素在根除幽门螺杆菌治疗中的效果及对ALT、AST水平的影响

The Effect of Rabeprazole Triple Therapy Combined with Clarithromycin in the Treatment of Helicobacter Pylori Eradication and Its Effect on ALT and AST Levels

目的综合分析雷贝拉唑三联疗法联合克拉霉素在根除幽门螺杆菌(helicobacter pylori,Hp)治疗中的效果及对丙氨酸氨基转移酶、天门冬氨酸氨基转移酶水平的影响。方法目的选取滨州市滨城区人民医院2023年1—12月收治的136例Hp感染患者。按照治疗方法不同分为对照组(68例,应用泮托拉唑钠肠溶胶囊+雷贝拉唑+阿莫西林药物治疗方法)、观察组(68例,在对照组基础上应用克拉霉素药物治疗方法),比较两组疗效。结果两组患者不良反应发生率比较,差异无统计学意义(P>0.05),观察组患者的临床治疗总有效率98.53%(67/68)、Hp清除率95.59%(65/68)高于对照组的86.76%(59/68)和76.47%(52/68),差异有统计学意义(χ^(2)=6.908、8.534,P均<0.05),观察组患者的临床症状消失时间短于对照组,差异有统计学意义(P均<0.05);治疗前后,两组患者的肝功能比较,差异无统计学意义(P均>0.05)。结论雷贝拉唑三联疗法联合克拉霉素可有效根除Hp,提高临床治疗效果、加速临床症状消失,且不会影响患者的肝功能,有效性和安全性均较高。

Objective To comprehensively analyze the effect of rabeprazole triple therapy combined with clarithromy-cin in the treatment of Helicobacter pylori(Hp)eradication and its effect on alanine aminotransferase and aspartate aminotransferase levels.Methods 136 Hp infected patients admitted to Bincheng District People's Hospital in Bin-zhou City from January to December 2023 were objectively selected.According to different treatment methods,they were divided into control group(68 cases,Application of pantoprazole sodium enteric-coated capsules+rabeprazole+amoxicillin drug treatment method)and observation group(68 cases,treated with clarithromycin on the basis of control group).The efficacy of the two groups was compared.Results There was no statistically significant difference in the in-cidence of adverse reactions between the two groups of patients(P>0.05).The clinical treatment total effective rate 98.53%(67/68)and Hp clearance rate 95.59%(65/68)of the observation group were higher than 86.76%(59/68)and 76.47%(52/68)of the control group,the differences were statistically significant(all P<0.05).The clinical symptom disappearance time of the observation group were shorter than those of the control group,the differences were statisti-cally significant(all P<0.05);There was no statistically significant difference in liver function between the two groups of patients before and after treatment(all P>0.05).Conclusion Rabeprazole triple therapy combined with clarithromy-cin can effectively eradicate Hp,improve clinical treatment efficacy,accelerate the disappearance of clinical symp-toms,and will not affect the liver function of patients,with high efficacy and safety.