β-内酰胺类抗生素在儿童呼吸道感染性疾病治疗中的应用价值分析

Analysis of the Application Value ofβ-Lactam Antibiotics in the Treat⁃ment of Children with Respiratory Tract Infectious Diseases

目的探讨β-内酰胺类抗生素应用在儿童呼吸道感染性疾病治疗中的价值。方法非随机选取2022年3月—2024年1月济宁市第三人民医院收治的76例呼吸道感染性疾病患儿为研究对象,按治疗方法不同分成对照组(38例,头孢噻肟钠治疗)和观察组(38例,头孢噻肟钠联合阿奇霉素治疗)。对比两组炎症因子水平、免疫功能及呼吸功能。结果治疗后观察组白细胞介素6(87.73±11.17)ng/L、C反应蛋白(2.27±0.68)mg/L水平均低于对照组的(106.89±15.74)ng/L、(3.88±0.87)mg/L,差异有统计学意义(t=7.675、12.564,P均<0.05);治疗后观察组T淋巴细胞亚群CD3+、CD4+、CD4+/CD8+高于对照组,而其CD8+水平低于对照组,差异有统计学意义(P均<0.05);治疗后观察组呼吸功能各项数值均优于对照组,差异有统计学意义(P均<0.05)。结论将β-内酰胺类抗生素应用在儿童呼吸道感染性疾病治疗中可明显改善其炎症因子水平、免疫功能及呼吸功能。

Objective To investigate the value ofβ-lactam antibiotics in the treatment of children with respiratory tract infectious diseases.Methods A total of seventy-six children with respiratory tract infectious diseases admitted to Jining Third People's Hospital from March 2022 to January 2024 were non-randomly selected as the study subjects,and divided into control group(thirty-eight cases treated with cefotaxime sodium)and observation group(thirty-eight cases treated with cefotaxime sodium combined with azithromycin)according to different treatment methods.The lev-els of inflammatory factors,immune function and respiratory function of the two groups were compared.Results After treatment,the levels of interleukin 6(87.73±11.17)ng/L and C-reactive protein(2.27±0.68)mg/L in the observation group were lower than those in the control group(106.89±15.74)ng/L and(3.88±0.87)mg/L,the difference were statis-tically significant(t=7.675,12.564,both P<0.05).After treatment,T lymphocyte subsets CD3+,CD4+,CD4+/CD8+in observation group were higher than those in control group,while CD8+levels were lower than those in control group,the differences were statistically significant(all P<0.05).After treatment,all the values of respiratory function in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion The application ofβ-lactam antibiotics in the treatment of children with respiratory tract infectious diseases can significantly improve the level of inflammatory factors,immune function and respiratory function.