茵栀黄口服液联合蓝光照射对病理性黄疸新生儿胆红素、心肌损害指标的影响

Effects of Yinzhihuang oral liquid combined with blue light irradiation for treating newborns with pathological jaundice on their levels of bilirubin and myocardial impairment indicators

目的:探讨茵栀黄口服液联合蓝光照射对病理性黄疸新生儿胆红素、心肌损害指标的影响。方法:选取2023年1-12月在本院进行治疗的病理性黄疸新生儿90例,随机数字表法分为对照组和观察组各45例,对照组给予蓝光照射治疗,观察组给予蓝光照射加用茵栀黄口服液治疗,比较两组临床疗效、胆红素[总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)]、炎性因子[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]、心肌损害指标[肌酸肌酶同工酶(CK-MB)、心肌肌钙蛋白(cTnI)]、神经功能损害指标[β-定粉酶样蛋白(Aβ)、神经元特异性烯醇化酶(NSE)、TBIL与白蛋白比值(B/A)]及不良反应。结果:观察组治疗有效率(93.3%)高于对照组(77.8%),胎便排空时间、黄疸消退和住院时间均短于对照组(均P<0.05)。治疗1周后,两组血清TBIL、DBIL、IBIL、TNF-α、CRP、IL-6、CK-MB、cTnI、Aβ、NSE、B/A水平均降低,且观察组各指标均低于对照组(均P<0.05)。不良反应发生率观察组(6.7%)与对照组(11.1%)无差异(P>0.05)。结论:蓝光照射联合茵栀黄口服液治疗病理性黄疸新生儿疗效提高,可促进患儿黄疸消退,降低胆红素、cTnI水平,保护心肌细胞和神经功能,有利于改善预后。

Objective: To investigate the effects of Yinzhihuang oral liquid combined with blue light irradiation for treating newborns with pathological jaundice on their levels of bilirubin and myocardial impairment indicators. Methods: 90 newborns with pathological jaundice who were treated in the hospital from January to December 2023 were selected as the study subjects. These newborns were divided into two groups(45 cases in each group) by the random number table. The newborns in the two groups were treated with blue light irradiation, while the newborns in the observation group were treated with Yinzhihuang oral liquid additionally. The clinical effect, the levels of bilirubin total bilirubin(TBIL), direct bilirubin(DBIL) and the indirect bilirubin(IBIL), the levels of inflammatory factors tumor necrosis factor-α(TNF-α), C-reactive protein(CRP) and interleukin-6(IL-6), the levels of myocardial impairment indicators, such as creatine kinase isoenzyme(CK-MB) and cardiac troponinc(cTnI), the levels of neurological impairment indicators, such as amyloid beta(Aβ), neuron specific enolase(NSE) and TBIL to albumin ratio(B/A), and the adverse reactions rate of the newborns were compared between the two groups. Results: The therapy efficacy(93.3%) of the newborns in the observation group was significantly higher than that(77.8%) of the newborns in the control group. The meconium emptying time, the jaundice subsided time, and duration of the hospital stay of the newborns in the observation group were significantly shorter than those of the newborns in the control group(all P<0.05). After 1 week of treatment, the levels of serum TBIL, DBIL, IBIL, TNF-α, CRP, IL-6, CK-MB, cTnI, Aβ, NSE, and B/A of the newborns in the two groups had decreased significantly, and which of the newborns in the observation group were significantly lower than those of the newborns in the control group(all P<0.05).The incidence of the adverse reactions(6.7%)of the newborns in observation group had no significantly different from that(11.1%)of the newborns in the control group(P>0.05).Conclusion:Yinzhihuang oral liquid combined with blue light irradiation for treating the newborns with pathological jaundice can increase the effectiveness,and which can promote their jaundice regression,decrease their levels of bilirubin and cTnI,and protect their myocardial cells and nerve function,and it is conducive to the prognosis of the newborns.