EMs患者血清CA125、EMAb水平及与术后复发关系

Correlation between the levels of serum carbohydrate antigen 125 and anti-endometrial antibody of the patients with endometriosis and their postoperative recurrence

目的:分析子宫内膜异位症(EMs)患者血清糖类抗原125(CA125)、抗子宫内膜抗体(EMAb)水平及与术后复发关系。方法:回顾性收集2017年3月-2021年3月本院确诊并行手术治疗的EMs患者112例病历资料,根据术后2年后是否复发分为复发组(n=32)和未复发组(n=80)。酶联免疫吸附试验检测血清CA125、EMAb水平,并分析血清CA125、EMAb水平与EMs术后复发关系。结果:两组术后血清CA125、EMAb水平均低于术前,但复发组(24.68±4.61 U/ml、0.32±0.07 ng/L)均高于未复发组(18.45±6.03 U/ml、0.25±0.06 ng/L)(均P<0.05)。两组痛经史、人工流产次数、既往宫腔操作史、盆腔炎、合并子宫肌瘤、多发病灶、临床分期、临床病理类型、术后妊娠情况、CA125及EMAb表达等均能有差异(P>0.05)。多因素回归分析,有痛经史(OR=3.025)、临床分期≥Ⅲ期(OR=3.077)、CA125阳性表达高(OR=2.3556)、EMAb阳性表达高(OR=2.323)均为影响EMs患者术后复发的独立危险因素(均P<0.05)。结论:EMs患者血清CA125、EMAb水平升高,可能为术后治疗复发评估潜在血清学指标。

Objective:To analyze the correlation between the levels of serum carbohydrate antigen 125(CA125)and anti-endometrial antibody(EMAb)of the patients with endometriosis(EMs)and their postoperative EMs recurrence.Methods:A retrospective analysis was performed on the medical records of 112 patients with Ems who had undergone the surgical treatment between March 2017 and March 2021.According to presence or absence of the postoperative recurrence of Ems,these patients were divided into group A(32 patients with EMs recurrence)and group B(80 patients without EMs recurrence).The levels of serum CA125 and EMAb of the patients were detected by enzyme-linked immunosorbent assay,and the correlation between the levels of serum CA125 and EMAb of the patients and their postoperative recurrence of EMs was analyzed.Results:The serum levels of CA125 and EMAb of the patients in the two groups after operation had decreased significantly,but the serum levels of CA125 and EMAb(24.68±4.61 U/ml and 0.32±0.07 ng/L)of the patients in group A were significantly higher than those(18.45±6.03 U/ml and 0.25±0.06 ng/L)of the patients in group B(all P<0.05).There were significant differences in the history of dysmenorrhea,the number of induced abortions,the history of uterine cavity operation,the pelvic inflammatory disease,the combined uterine fibroids,the multiple lesions,the clinical stage,the clinical pathological type,the postoperative pregnancy situation and the levels of CA125 and EMAb of the patients between the two groups(P<0.05).Multivariate regression analysis showed that the history of dysmenorrhea(OR=3.025),the clinical stage of EMs≥Ⅲstaging(OR=3.077),the high positive expression level of CA125(OR=2.3556),and the high positive expression level of EMAb(OR=2.323)of the patients were the independent risk factors of their postoperative recurrence of EMs(all P<0.05).Conclusion:The serum CA125 and EMAb levels of the patients with Ems increase,and which can be applied as the potential serum indexes for evaluating the postoperative recurrence of EMT of the patients.