IVIM-DWI参数联合DCE-MRI参数对肝癌患者经肝动脉化疗栓塞治疗后复发的预测价值

Predictive Value of IVIM-DWI Parameters Combined with DCE-MRI Parameters for Recurrence After Transcatheter Arterial Chemoembolization Treatment in Patients with Hepatocellular Carcinoma

目的探讨体素内不相关运动扩散加权成像(IVIM-DWI)参数联合磁共振动态对比增强(DCE-MRI)参数对肝癌患者经肝动脉化疗栓塞(TACE)治疗后复发的预测价值。方法160例经TACE治疗有效的肝癌患者根据复发情况分为复发组和未复发组,比较两组的IVIM-DWI参数(D、D^(*)、ADC)、DCE-MRI参数(K_(trans)、K_(ep)、V_(e)),分析相关参数对肝癌患者TACE治疗后复发的预测价值。结果复发组的D低于未复发组,D^(*)、K_(trans)、K_(ep)均高于未复发组(P<0.05);两组的ADC、V_(e)比较,差异无统计学意义(P>0.05)。ROC曲线显示,D^(*)、D、K_(trans)、K_(ep)联合对肝癌患者TACE治疗后复发具有良好的预测价值(AUC=0.814)。结论IVIM-DWI参数联合DCE-MRI参数可有效预测肝癌患者TACE治疗后的复发情况。

Objective To explore the predictive value of intravoxel incoherent motion diffusion-weighted imaging(IVIM-DWI)parameters combined with dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters for recurrence after transcatheter arterial chemoembolization(TACE)treatment in patients with hepatocellular carcinoma.Methods According to the recurrence situation,160 patients with hepatocellular carcinoma who were effective in TACE treatment were divided into the recurrence group and the nonrecurrence group.The IVIM-DWI parameters(D,D^(*),ADC)and DCE-MRI parameters(K_(trans),K_(ep),V_(e))of the two groups were compared,and the predictive value of the relevant parameters for the recurrence of patients with hepatocellular carcinoma after TACE treatment was analyzed.Results The D of the recurrence group was lower than that of the non-recurrence group,and the D^(*),K_(trans) and K_(ep) were higher than those of the non-recurrence group(P<0.05).ROC curve showed that the combination of D^(*),D,K_(trans) and K_(ep) had good predictive value for recurrence after TACE treatment in patients with hepatocellular carcinoma(AUC=0.814).Conclusions IVIM-DWI parameters combined with DCE-MRI parameters can effectively predict the recurrence of patients with hepatocellular carcinoma after TACE treatment.