还原型谷胱甘肽联合高流量氧疗治疗慢性阻塞性肺疾病急性加重期患者的临床效果

Clinical Effect of Reduced Glutathione Combined with High-Flow Oxygen Therapy in the Treatment of Patients with AcuteExacerbation of Chronic Obstructive Pulmonary Disease

目的探讨还原型谷胱甘肽(GSH)联合高流量氧疗治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的效果。方法80例AECOPD患者随机分为两组,对照组给予高流量氧疗治疗,研究组给予GSH联合高流量氧疗治疗,比较两组的临床疗效、血气指标以及炎性因子水平。结果治疗2周后,研究组的总有效率、PaO_(2)均高于对照组,PaCO_(2)以及血清PCT、CRP水平均低于对照组(P<0.05)。结论GSH联合高流量氧疗可改善AECOPD患者的血气指标,缓解患者的炎性反应。

Objective To explore the effect of reduced glutathione(GSH)combined with high-flow oxygen therapy in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods 80 patients with AECOPD were randomly divided into two groups.The control group was treated with high-flow oxygen therapy,and the study group was treated with GSH combined with high-flow oxygen therapy.The clinical efficacy,blood gas indicators and inflammatory factor levels were compared between the two groups.Results After 2 weeks of treatment,the total effective rate and PaO_(2) in the study group were higher than those in the control group,and PaCO_(2) and the levels of serum PCT and CRP were lower than those in the control group(P<0.05).Conclusions GSH combined with high-flow oxygen therapy can improve the blood gas indicators and alleviate the inflammatory reaction of patients with AECOPD.