膏方调治儿童厌食症临床效果的meta分析

Clinical effect of Gaofang in the treatment of anorexia in children:a meta-analysis

目的系统评价膏方调治儿童厌食症的临床效果。方法通过计算机检索知网、维普、中国生物医学文献服务系统、万方及PubMed 5个数据库,检索时间自建库至2024年2月5日,搜集膏方治疗儿童厌食症的随机对照试验,采用RevMan 5.3软件进行meta分析。结果共纳入20篇文献,1630例患儿。meta分析结果显示:与对照组比较,试验组临床总有效更高[RR=1.22,95%CI(1.17,1.27),P<0.00001],中医证候总积分更低[MD=-3.12,95%CI(-3.77,-2.47),P<0.00001],锌、铁浓度更高[SMD=0.96,95%CI(0.63,1.29),P<0.00001;SMD=1.54,95%CI(0.61,2.47),P=0.001],体重更大[MD=1.37,95%CI(0.20,2.55),P=0.02]。结论膏方调治儿童厌食症可改善临床症状,提升微量元素水平,增加体重,但有待更多优质研究加以验证。

Objective To systematically evaluate the clinical effect of Gaofang in the treatment of anorexia in children.Methods CNKI,VIP,SinoMed,WanFang Data and PubMed databases were searched from the establishment of the database to February 5,2024 to collect randomized controlled trials of the Gaofang in the treatment of anorexia in children.RevMan 5.3 software was used for meta-analysis.Results A total of 20 literature was included,involving 1630 children.The results of meta-analysis showed that compared with the control group,the total clinical effective rate of the experimental group was higher(RR=1.22,95%CI[1.17,1.27],P<0.00001),and the total traditional Chinese medicine syndrome score was lower(MD=-3.12,95%CI[-3.77,-2.47],P<0.00001),and the levels of zinc and iron were higher(SMD=0.96,95%CI[0.63,1.29],P<0.00001;SMD=1.54,95%CI[0.61,2.47],P=0.001),and the body weight was higher(MD=1.37,95%CI[0.20,2.55],P=0.02).Conclusion Gaofang in the treatment of anorexia in children can improve clinical symptoms,increase micronutrient levels,and increase body weight,but more high-quality studies are needed to confirm this.