高尿酸血症发病机制与治疗策略的研究进展

Research progress on the pathogenesis and treatment strategies of hyperuricemia

高尿酸血症(HUA)患病率逐年攀升,已经跃升为威胁人类健康的第二大代谢性疾病,与高血压、高血脂、高血糖并称“四高”。研究发现,HUA的发生发展与性别、环境、遗传等因素有关,其中尿酸代谢与肾脏尿酸转运系统及肠道菌群密切相关。药物治疗与非药物治疗策略都是围绕减少尿酸来源、增加尿酸排泄进行的。本文将围绕流行病学、病因学、代谢途径和治疗策略等角度对HUA的最新研究进展进行综述,这不仅有助于阐明HUA发病机制,也为进一步降尿酸策略的研发提供了理论依据,以期为后续深入研究提供参考。

The prevalence of hyperuricemia(HUA)has been rising year by year,which has become the second largest metabolic disease threatening human health,and is known as the“four highs”together with hypertension,hyperlipidemia and hyperglycemia.Studies have found that the occurrence and development of HUA are related to gender,environment,genetics and other factors,among which uric acid metabolism is closely related to the renal uric acid transport system and intestinal flora.Both drug and non-drug treatment strategies focus on reducing uric acid sources and increasing uric acid excretion.Therefore,this paper will review the latest research advances in HUA from epidemiology,etiology,metabolic pathways,and treatment strategies,which not only helps to clarify the pathogenesis of HUA,but also provides a theoretical basis for further research and development of uric acid lowering strategies,in order to serve as a reference for subsequent in-depth studies.