高压氧对ACI患者神经功能恢复、血清VEGF、Ang-2、NSE的影响

The effects of hyperbaric oxygen on neurological function recovery,serum VEGF,Ang-2,and NSE in ACI patients

目的 探讨高压氧治疗急性脑梗死(ACI)的疗效及对血清血管内皮生长因子(VEGF)、血管生成素-2(Ang-2)、神经特异性烯醇化酶(NSE)、可溶性细胞黏附分子-1(sICAM-1)和单核细胞趋化蛋白-1(MCP-1)的影响。方法 将选取的ACI患者130例分为观察组(n=66)和对照组(n=64)。对照组给予常规治疗,观察组在对照组基础给予高压氧治疗。观察两组治疗疗效,神经功能[美国国立卫生研究院卒中量表(NIHSS)评分]、生活能力[日常生活活动(ADL)评分],检测治疗前后VEGF、Ang-2、NSE、sICAM-1、MCP-1水平以及脑血流速度(CBF)、脑血流量(CBV)。结果 观察组治疗疗效优于对照组(P<0.05);与治疗前比较,治疗后两组NIHSS评分、NSE、sICAM-1、MCP-1降低,且观察组低于对照组(P<0.05);ADL评分、CBF、CBV、VEGF、Ang-2升高,且观察组高于对照组(P<0.05)。结论 高压氧对ACI有较好的疗效,能显著改善患者脑血管灌注量,促进神经功能恢复,提高生活质量及血清VEGF、Ang-2等水平。

Aim To investigate the effects of hyperbaric oxygen on acute cerebral infarction(ACI) and its effects on serum vascular endothelial growth factor(VEGF),angiopoietin-2(Ang-2),neurospecific enolase(NSE),soluble cell adhesion molecule-1(sICAM-1) and monocyte chemoattractant protein-1(MCP-1).Methods 130 ACI patients were randomly divided into observation group(n=66) and control group(n=64) by randomized number table method.The control group was given routine treatment,while the observation group was given hyperbaric oxygen therapy on the basis of the control group.The neurological function(national institute of health stroke scale(NIHSS)) and life ability(activity of daily living(ADL)),the levels of VEGF,Ang-2,NSE,sICAM-1,MCP-1,cerebral blood flow velocity(CBF) and cerebral blood flow volume(CBV) and so on were measured before and after treatment.Results The curative effect of the observation group was better than that of the control group(P<0.05).Compared with the parameters before treatment,the NIHSS score,NSE,sICAM-1,and MCP-1 in both groups were decreased after treatment,and the observation group was lower than the control group(P<0.05).ADL score,CBF,CBV,VEGF,and Ang-2 were increased,and the observation group was higher than the control group(P<0.05).Conclusion Hyperbaric oxygen therapy has a good effect on ACI,which can significantly improve cerebral vascular perfusion,promote the recovery of neurological function,improve quality of life,serum vascular endothelial growth factor,Ang-2 and other indicators.