新疆地区单中心315例汉族和维吾尔族溃疡性结肠炎临床特点分析

Clinical characteristics of 315 Han and Uyghur ulcerative colitis patients in a single center in Xinjiang Uygur Autonomous Region

目的分析新疆地区单中心汉族和维吾尔族溃疡性结肠炎(UC)的临床特点。方法回顾性纳入2015年1月至2023年6月于新疆维吾尔自治区人民医院住院且临床资料完整的UC患者,分析汉族和维吾尔族UC的基本信息、肠外表现及实验室指标的差异。结果纳入315例UC患者,其中汉族172例(54.6%),维吾尔族143例(45.4%)。与汉族组比较,维吾尔族组以女性为主,具有较低平均年龄、吸烟率和饮酒率(P均<0.05)。肠外表现中,维吾尔族组与汉族组主要在肝胆疾病和关节损伤的比例较高,但两组差异无统计学意义(P均>0.05)。在并发症中,汉族UC具有较高的上皮内瘤变水平,差异有统计学意义(χ^(2)=5.075,P<0.05)。与汉族组比较,维吾尔族组白细胞、血小板计数、中性粒细胞数、淋巴细胞数、球蛋白、C-反应蛋白、红细胞沉降率、超敏C反应蛋白、抗中性粒细胞胞质抗体、幽门螺杆菌抗体相关指标升高,差异均有统计学意义(P均<0.05)。临床疗效评定上,汉族和维吾尔族UC患者均能取得较好的临床疗效。结论维吾尔族UC发病年龄较小、疾病严重程度较重,合适的治疗方案均能够得到满意的临床疗效。

ObjectiveTo analyze the clinical characteristics of ulcerative colitis(UC)in Han and Uyghur patients in Xinjiang Uygur Autonomous Region.MethodData of UC patients hospitalized at the People′s Hospital of Xinjiang Uygur Autonomous Region from January 2015 to June 2023 were retrospectively collected,with a focus on the differences in basic information,extraintestinal manifestations and biochemical laboratory indicators between Han and Uyghur patients.ResultsA total of 315 UC patients were included,with 172 Han cases(54.6%)and 143 Uyghur cases(45.4%).Compared to the Han group,the Uyghur group had a higher proportion of females,a lower average age,and lower rates of smoking and alcohol consumption(all P<0.05).The Uyghur group showed a higher prevalence of hepatobiliary diseases and joint injuries as extraintestinal manifestations,although the differences were not statistically significant(P all>0.05).The Han group had a statistically significant higher level of intraepithelial neoplasia(χ^(2)=5.075,P<0.05).The Uyghur group exhibited significantly higher levels of white blood cell count,platelet count,neutrophils,lymphocyte count,globulin,C-reactive protein,erythrocyte sedimentation rate,highly sensitive C-reactive protein,anti-neutrophil cytoplasmic antibodies,and H.pylori antibodies compared to the Han group(all P<0.05).Both Han and Uyghur UC patients achieved satisfactory clinical efficacy.ConclusionUyghur UC patients have distinct characteristics,including a younger age of onset and more severe disease course,yet appropriate treatment can lead to satisfactory clinical outcomes.