植物ABA信号转导途径中选择性剪接的研究进展

Research progress on alternative splicing of ABA signaling in plants

选择性剪接(alternative splicing,AS)是真核细胞中一种重要的转录后调控方式。前体mRNA通过不同的剪接方式产生多样的成熟转录本,翻译成蛋白质,进而调节多种生命活动。脱落酸(abscisic acid,ABA)是一种重要的植物激素,主要参与调控种子休眠、根系发育、叶片衰老、器官脱落及对环境胁迫的反应等。之前的研究表明,选择性剪接在ABA信号转导过程中发挥着重要作用。本综述阐明了已鉴定的ABA信号通路中AS相关的剪接因子和ABA反应中经历AS的相关基因及其机制的最新进展,展示了它们如何与ABA敏感性、种子休眠等过程产生联系,并对未来的研究方向作出一定预测,以期为植物生产实践中培育抗逆优良性状的作物品种提供一定理论基础。

Alternative splicing(AS)is an important post-transcriptional regulation mode in eukaryotic cells,in which precursor mRNA produces a variety of mature transcripts through different splicing methods,and then translates a variety of proteins to regulate a variety of life activities.Abscisic acid is an important plant hormone involved in the regulation of seed dormancy,root development,leaf senescence,organ shedding and response to environmental stress.Studies have shown that alternative splicing plays an important role in ABA signaling.In this review,we review the recent progress of the identified AS-related splicing factors in the ABA signaling pathway and the genes related to AS-undergoing in the ABA response and their mechanisms,and show how they are related to ABA sensitivity,seed dormancy,flowering transformation and other processes,and make some predictions for future research directions,in order to provide a theoretical basis for constructingcrops with stress resistence specific qualities and cultivating individuals with excellent traits.