维生素AD滴剂联合小儿豉翘清热颗粒治疗反复呼吸道感染患儿的效果

Effects of Vitamin A and D drops combined with Xiaoer Chiqiao Qingre granules in treatment of children with recurrent respiratory tract infection

目的:观察维生素AD滴剂联合小儿豉翘清热颗粒治疗反复呼吸道感染患儿的效果。方法:选取2021年2月至2022年2月该院收治的82例反复呼吸道感染患儿进行前瞻性研究,按照随机数字表法将其分为观察组和对照组各41例。两组均予以常规治疗,在此基础上,对照组予以小儿豉翘清热颗粒治疗,观察组在对照组基础上联合维生素AD滴剂治疗,两组均连续治疗2周。比较两组临床疗效、临床症状(咳嗽、发热、喘息)消失时间、治疗前后免疫球蛋白指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)]水平以及不良反应发生率。结果:观察组治疗总有效率为90.24%(37/41),高于对照组的73.17%(30/41),差异有统计学意义(P<0.05);观察组咳嗽、发热、喘息等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组IgA、IgG水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:维生素AD滴剂联合小儿豉翘清热颗粒治疗反复呼吸道感染患儿可提高治疗总有效率和免疫球蛋白指标水平,缩短临床症状消失时间,效果优于单纯小儿豉翘清热颗粒治疗。

Objective:To observe effects of Vitamin A and D drops combined with Xiaoer Chiqiao Qingre granules in treatment of children with recurrent respiratory tract infection.Methods:A prospective study was conducted on 82 children with recurrent respiratory tract infection admitted to the hospital from February 2021 to February 2022.According to the random number table method,they were divided into observation group and control group,41 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Xiaoer Chiqiao Qingre granules,while the observation group was treated with Vitamin A and D drops on the basis of that of the control group.Both groups were treated for 2 weeks.The clinical efficacy,the disappearance time of clinical symptoms(cough,fever,wheezing),the levels of immunoglobulin indexes[immunoglobulin A(IgA),immunoglobulin G(IgG)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 90.24%(37/41),which was higher than 73.17%(30/41)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of clinical symptoms such as cough,fever and wheezing in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IgA and IgG in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Vitamin A and D drops combined with Xiaoer Chiqiao Qingre granules in the treatment of the children with recurrent respiratory tract infection can improve the total effective rate and the immunoglobulin index levels,and shorten the disappearance time of clinical symptoms.Moreover,it is superior to simple Xiaoer Chiqiao Qingre granules.