甲泼尼龙联合阿奇霉素治疗肺炎支原体肺炎患儿的效果

Effects of Methylprednisolone combined with Azithromycin in treatment of children with mycoplasma pneumoniae pneumonia

目的:观察甲泼尼龙联合阿奇霉素治疗肺炎支原体肺炎患儿的效果。方法:选取2021年9月至2023年11月该院收治的80例肺炎支原体肺炎患儿进行前瞻性研究。依据随机数字表法将其分为对照组与研究组各40例。对照组给予阿奇霉素治疗,研究组在对照组基础上联合甲泼尼龙治疗。比较两组临床疗效、临床症状(咳嗽、肺部阴影、发热、肺部啰音)消失时间、住院时间,治疗前后肺功能指标[最大呼气流速(PEF)、第1秒用力呼气容积(FEV1)、用力肺活量(FVC)]水平,以及不良反应发生率。结果:研究组治疗总有效率为97.50%(39/40),高于对照组的80.00%(32/40),差异有统计学意义(P<0.05);研究组肺部啰音、发热、咳嗽、肺部阴影等临床症状消失时间和住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组PEF、FEV1、FVC水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:甲泼尼龙联合阿奇霉素治疗肺炎支原体肺炎患儿可提高治疗总有效率和肺功能指标水平,以及缩短临床症状消失时间和住院时间的效果优于单纯阿奇霉素治疗。

Objective:To observe effects of Methylprednisolone combined with Azithromycin in treatment of children with mycoplasma pneumoniae pneumonia.Methods:A prospective study was conducted on 80 children with mycoplasma pneumoniae pneumonia admitted to this hospital from September 2021 to November 2023.According to the random number table method,they were divided into control group and study group,40 cases in each group.The control group was treated with Azithromycin,while the study group was treated with Methylprednisolone on the basis of that of the control group.The clinical efficacy,the disappearance time of clinical symptoms(cough,lung shadow,fever,lung rale),the hospitalization time,the lung function indexes[maximum expiratory flow rate(PEF),forced expiratory volume in one second(FEV1),forced vital capacity(FVC)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 97.50%(39/40),which was higher than 80.00%(32/40)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of clinical symptoms such as pulmonary rales,fever,cough,lung shadow and the hospitalization time in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PEF,FEV1 and FVC in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Methylprednisolone combined with Azithromycin in the treatment of the children with mycoplasma pneumoniae pneumonia can improve the total effective rate of treatment and the levels of lung function indexes,and shorten the disappearance time of clinical symptoms and the hospitalization time.Moreover,it is superior to simple Azithromycin treatment.