苏黄止咳胶囊联合氨茶碱治疗慢性支气管炎患者的效果

Effects of Suhuang Zhike capsules combined with Aminophylline in treatment of patients with chronic bronchitis

目的:观察苏黄止咳胶囊联合氨茶碱治疗慢性支气管炎患者的效果。方法:选取2019年8月至2023年8月该院收治的200例慢性支气管炎患者进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各100例。对照组给予氨茶碱治疗,研究组在对照组基础上联合苏黄止咳胶囊治疗。比较两组临床疗效,治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、FEV_(1)/FVC]水平、中医证候(咳嗽气粗、咽痛喉燥、鼻流黄涕)积分、炎性因子[C反应蛋白(CRP)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)]水平,以及不良反应发生率。结果:研究组治疗总有效率为96.00%(96/100),高于对照组的88.00%(88/100),差异有统计学意义(P<0.05);治疗后,两组FVC、FEV_(1)水平及FEV_(1)/FVC均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组咳嗽气粗、咽痛喉燥及鼻流黄涕等中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、IL-4水平均低于治疗前,且研究组低于对照组,两组IL-10水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:苏黄止咳胶囊联合氨茶碱治疗慢性支气管炎患者可提高临床疗效,改善肺功能,降低中医证候积分,减轻机体炎症反应,效果优于单纯氨茶碱治疗。

Objective:To observe effects of Suhuang Zhike capsules combined with Aminophylline in treatment of patients with chronic bronchitis.Methods:A prospective study was conducted on 200 patients with chronic bronchitis admitted to the hospital from August 2019 to August 2023.According to the random number table method,they were divided into control group and study group,100 cases in each group.The control group was treated with Aminophylline,while the study group was treated with Suhuang Zhike capsules on the basis of that of the control group.The clinical efficacy,the lung function indexes[forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1)),FEV_(1)/FVC]levels,the TCM syndrome(cough,sore throat and dry throat,yellow nasal discharge)scores,the inflammatory factors[C-reactive protein(CRP),interleukin-4(IL-4),interleukin-10(IL-10)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 96.00%(96/100),which was higher than 88.00%(88/100)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FVC,FEV_(1) and FEV_(1)/FVC in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The scores of TCM syndromes such as cough,sore throat and dry throat and yellow nasal discharge in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP and IL-4 in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the levels of IL-10 in the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Suhuang Zhike capsules combined with Aminophylline in the treatment of the patients with chronic bronchitis can improve the clinical efficacy,improve the lung function,reduce the TCM syndrome scores,and reduce the body’s inflammatory response.Moreover,it is superior to simple Aminophylline treatment.