半夏泻心汤联合常规四联疗法治疗幽门螺杆菌相关性胃炎患者的效果

Effects of Banxia Xiexin decoction combined with conventional quadruple therapy in treatment of Helicobacter pylori-associated gastritis

目的:观察半夏泻心汤联合常规四联疗法治疗幽门螺杆菌(Hp)相关性胃炎患者的效果。方法:回顾性分析2022年7月至2023年9月该院收治的102例Hp相关性胃炎患者的临床资料,根据治疗方法不同将其分为对照组和观察组各51例。对照组采用常规四联疗法治疗,观察组在对照组基础上联合半夏泻心汤治疗,比较两组临床疗效,Hp根除率,治疗前后胃蛋白酶原(PG,PGⅠ、PGⅡ)水平、胃肠激素[生长抑素(SS)、胃泌素-17(G-17)、胃动素(MTL)]水平,以及不良反应发生率。结果:观察组治疗总有效率为96.08%(49/51),高于对照组的82.35%(42/51),差异有统计学意义(P<0.05);观察组Hp根除率为92.16%(47/51),高于对照组的76.47%(39/51),差异有统计学意义(P<0.05);治疗后,两组血清PGⅠ、PGⅡ水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组SS水平均高于治疗前,且观察组高于对照组,两组G-17、MTL水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:半夏泻心汤联合常规四联疗法治疗Hp相关性胃炎患者可提高临床疗效和Hp根除率,增高胃蛋白酶原水平,调节胃肠激素分泌,效果优于常规四联疗法治疗。

Objective:To observe effects of Banxia Xiexin decoction combined with conventional quadruple therapy on patients with Helicobacter pylori(Hp)-associated gastritis.Methods:The clinical data of 102 patients with Hp-associated gastritis admitted to the hospital from July 2022 to September 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,51 cases in each group.The control group was treated with conventional quadruple therapy,while the observation group was treated with Banxia Xiexin decoction on the basis of that of the control group.The clinical efficacy,the Hp eradication rate,the pepsinogen(PG;PGI,PGII)levels,the gastrointestinal hormones[somatostatin(SS),gastrin-17(G-17),motilin(MTL)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.08%(49/51),which was higher than 82.35%(42/51)of the control group,and the difference was statistically significant(P<0.05).The Hp eradication rate in the observation group was 92.16%(47/51),which was higher than 76.47%(39/51)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of serum PGI and PGII in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The SS levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the levels of G-17 and MTL in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Banxia Xiexin decoction combined with conventional quadruple therapy can improve the clinical efficacy and the Hp eradication rate,increase the levels of pepsinogen and improve the secretion of gastrointestinal hormones in the patients with Hp-related gastritis.Moreover,it is superior to conventional quadruple therapy.