外周血NLR、NHR、MHR联合检测在小儿急性肾小球肾炎诊断中的效能

Efficiency of combined detection of peripheral blood NLR,NHR and MHR levels in diagnosis of acute glomerulonephritis in children

目的:分析外周血中性粒细胞与淋巴细胞比值(NLR)、中性粒细胞与高密度脂蛋白比值(NHR)、单核细胞与高密度脂蛋白比值(MHR)联合检测在小儿急性肾小球肾炎(AGN)诊断中的效能。方法:选取2022年7月至2023年6月该院收治的70例AGN患儿进行前瞻性研究,依据急性肾损伤(AKI)分期标准,将患儿分为AKI 1期、AKI 2期、AKI 3期,另选取30名体检健康儿童,设为对照组。比较所有受试者外周血NLR、NHR、MHR;采用Spearman相关性分析外周血NLR、NHR、MHR与AGN患儿AKI分期的相关性;绘制受试者工作特征(ROC)曲线分析外周血NLR、NHR、MHR单项及联合检测在AGN诊断中的效能。结果:AKI 1期、2期、3期患儿的NLR、NHR、MHR均高于对照组,且AKI 2期、3期均高于AKI 1期,AKI 3期高于AKI 2期,差异有统计学意义(P<0.05);Spearman相关性分析结果显示,外周血NLR、NHR、MHR与AGN患儿AKI分期呈正相关(r>0,P<0.05);ROC曲线分析结果显示,外周血NLR、NHR、MHR单项及联合检测诊断AGN的曲线下面积(AUC)分别为0.789、0.790、0.734、0.902,均具有一定诊断效能,其中联合检测诊断AGN的效能高于三者单项检测诊断效能。结论:外周血NLR、NHR、MHR联合检测诊断AGN的效能高于三者单项检测诊断效能。

Objective:To analyze efficiency of combined detection of peripheral blood neutrophil to lymphocyte ratio(NLR),neutrophil to high-density lipoprotein ratio(NHR),monocyte to high-density lipoprotein ratio(MHR)in diagnosis of acute glomerulonephritis(AGN)in children Methods:A prospective study was conducted on 70 children with AGN admitted to this hospital from July 2022 to June 2023.According to the staging criteria of acute kidney injury(AKI),these patients were divided into AKI stage 1,AKI stage 2 and AKI stage 3.Another 30 healthy children were selected as the control group.The levels of NLR,NHR and MHR in the peripheral blood of all subjects were compared.Spearman correlation analysis was used to analyze the correlations among the peripheral blood NLR,NHR,MHR levels and the AKI stage in the children with AGN.The receiver operating characteristic(ROC)curve was drawn to analyze the efficiencies of single and combined detection of peripheral blood NLR,NHR and MHR levels in the diagnosis of AGN.Results:The levels of NLR,NHR and MHR in the children with AKI stage 1,2 and 3 were higher than those in the control group;the levels of NLR,NHR and MHR in the children with AKI stage 2 and 3 were higher than those in the children with AKI stage 1;the levels of NLR,NHR and MHR in the children with AKI stage 3 were higher than those in the children with AKI stage 2;and the differences were statistically significant(PP<0.05).The Spearman correlation analysis results showed that the levels of NLR,NHR,and MHR in the peripheral blood were positively correlated with the AKI staging in the children with AGN(r>0,P<0.05).The ROC curve showed that the areas under the curve(AUC)of single and combined detection of peripheral blood NLR,NHR and MHR levels was 0.789,0.790,0.734 and 0.902,separately,all of which had certain diagnostic efficiency,but the efficiency of combined detection in the diagnosis of AGN was higher than that of single detection.Conclusions:The efficiency of combined detection of peripheral blood NLR,NHR and MHR levels in the diagnosis of AGN is higher than that of single detection of the three.