血清AFP、NSE、CA72-4水平联合检测在非小细胞肺癌分期诊断中的效能

Efficiency of combined detection of serum AFP,NSE and CA72-4 levels in staging diagnosis of non-small cell lung cancer

目的:探讨血清甲胎蛋白(AFP)、神经元特异性烯醇化酶(NSE)、糖类抗原72-4(CA72-4)水平联合检测在非小细胞肺癌(NSCLC)分期诊断中的效能。方法:回顾性分析2021年6月至2023年10月该院收治的80例NSCLC患者的临床资料,设为肺癌组,并根据病理组织检查结果将其分为早期和中晚期;另选取同期20例肺部良性病变患者设为良性组,再选取同期50名健康体检者设为对照组,比较三组及不同分期NSCLC患者血清AFP、NSE、CA72-4水平,采用受试者工作特征(ROC)曲线分析其单项及联合检测在NSCLC分期诊断中的效能。结果:三组血清AFP、NSE、CA72-4水平比较,肺癌组>良性组>对照组,差异均有统计学意义(P<0.05);早期NSCLC患者血清AFP、NSE、CA72-4水平均低于中晚期NSCLC患者,差异有统计学意义(P<0.05);ROC曲线分析结果显示,血清AFP、NSE、CA72-4水平单项及联合检测诊断NSCLC早期的曲线下面积分别为0.816、0.807、0.832、0.912,联合检测诊断效能高于三者单项检测。结论:血清AFP、NSE、CA72-4水平联合检测诊断NSCLC早期的效能高于三者单项检测。

Objective:To investigate efficiency of serum alpha-fetoprotein(AFP),neuron specific enolase(NSE)and carbohydrate antigen 72-4(CA72-4)in staging diagnosis of non-small cell lung cancer(NSCLC).Methods:The clinical data of 80 patients with NSCLC admitted to this hospital from June 2021 to October 2023 were retrospectively analyzed and they set as the lung cancer group.According to the results of pathological examination,they were divided into early and advanced stage.A total of 20 patients with benign pulmonary lesions were selected as the benign group.A total of 50 healthy subjects in the same period were selected as the control group.The levels of serum AFP,NSE and CA72-4 were compared among the three groups and the NSCLC patients with different stages.The receiver operating characteristic(ROC)curve was used to analyze the efficiencies of single and combined detection in the staging diagnosis of NSCLC.Results:The comparison of the levels of serum AFP,NSE and CA72-4 among the three groups showed,lung cancer group>benign group>control group,and the differences were statistically significant(P<0.05).The levels of serum AFP,NSE and CA72-4 in the patients with early stage NSCLC were lower than those in the patients with advanced stage NSCLC,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the area under the curve of single and combined detection of serum AFP,NSE and CA72-4 levels in the diagnosis of early stage NSCLC were 0.816,0.807,0.832 and 0.912,respectively;and the diagnostic efficiency of combined detection was higher than that of single detection.Conclusions:The efficiency of combined detection of serum AFP,NSE and CA72-4 levels in the diagnosis of early NSCLC is higher than that of single detection of the three.