药学干预在喹诺酮类抗菌药物处方中的应用效果

Application effects of pharmaceutical intervention in prescription of Quinolone antibiotics

目的:观察药学干预在喹诺酮类抗菌药物处方中的应用效果。方法:选取2021年6月至2022年6月该院采用常规用药管理的85例患者(喹诺酮类抗菌药物处方245张)作为对照组,选取2022年7月至2023年7月该院采用药学干预的83例患者(喹诺酮类抗菌药物处方252张)作为观察组。比较两组不合理用药处方发生率、医师喹诺酮类抗菌药物知识知晓评分、喹诺酮类抗菌药物治疗相关指标水平。结果:观察组选药不合理、配伍禁忌、用法用量不合理、重复用药、药物相互作用等不合理用药处方发生率均低于对照组,差异有统计学意义(P<0.05);观察组医师喹诺酮类抗菌药物知识知晓评分高于对照组,差异有统计学意义(P<0.05);观察组用药时间短于对照组,不良反应发生率、药物利用指数、耐药菌株数均低于对照组,差异有统计学意义(P<0.05)。结论:药学干预可提高喹诺酮类抗菌药物处方的医师喹诺酮类抗菌药物知识知晓评分,以及降低不合理用药处方发生率和喹诺酮类抗菌药物治疗相关指标水平的效果优于单纯常规用药管理。

Objective:To observe application effects of pharmaceutical intervention in prescription of Quinolone antibiotics.Methods:From June 2021 to June 2022,85 patients(245 prescriptions of Quinolones antibiotics)with routine medication management in this hospital were selected as the control group,and 83 patients(252 prescriptions of Quinolones antibiotics)with pharmaceutical intervention from July 2022 to July 2023 were selected as the observation group.The incidence of irrational drug use prescriptions,the physicians’Quinolone antibiotics knowledge awareness scores,and the Quinolone antibiotics treatment-related index levels were compared between the two groups.Results:The incidence of irrational drug use prescriptions such as unreasonable drug selection,incompatibility,unreasonable usage and dosage,repeated drug use,and drug interaction in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The physicians’Quinolone antibiotics knowledge awareness score in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Further,the medication time of the observation group was shorter than that of the control group,the incidence of adverse reactions,drug utilization index and the number of drug-resistant strains were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusions:Pharmaceutical intervention can improve the physicians’Quinolone antibiotics knowledge awareness scores,and reduce the incidence of irrational drug prescription and the Quinolone antibiotics treatment-related index levels.Moreover,it is superior to simple routine medication management.