艾普拉唑钠与艾司奥美拉唑钠治疗消化性溃疡出血患者的效果比较

Comparison of effects of Ilaprazole sodium and Esomeprazole sodium in treatment of patients with peptic ulcer hemorrhage

目的:比较艾普拉唑钠与艾司奥美拉唑钠治疗消化性溃疡出血患者的效果。方法:选取2021年6月至2023年6月该院收治的100例消化性溃疡出血患者进行前瞻性研究,按随机数字表法将其分为研究组与对照组各50例。对照组采用注射用艾司奥美拉唑钠治疗,研究组采用注射用艾普拉唑钠治疗。比较两组止血成功率、再出血率,治疗前后凝血功能指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]水平和不良反应发生率。结果:研究组止血成功率高于对照组,再出血率低于对照组,差异均有统计学意义(P<0.05);治疗后,两组PT、APTT均短于治疗前,且研究组短于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:艾普拉唑钠治疗消化溃疡出血患者可提高止血成功率,改善凝血功能指标水平,以及降低再出血率、不良反应发生率的效果优于艾司奥美拉唑钠治疗。

Objective:To compare effects of Ilaprazole sodium and Esomeprazole sodium in treatment of patients with peptic ulcer hemorrhage.Methods:A prospective study was conducted on 100 patients with peptic ulcer hemorrhage admitted to this hospital from June 2021 to June 2023.According to the random number table method,they were divided into study group and control group,50 cases in each group.The control group was treated with Esomeprazole sodium for injection,while the study group was treated with Ilaprazole sodium for injection.The success rate of hemostasis,the rebleeding rate,the levels of coagulation function indexes[prothrombin time(PT),activated partial thromboplastin time(APTT)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The success rate of hemostasis in the study group was higher than that in the control group,the rebleeding rate was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the PT and APTT in the two groups were shorter than those before the treatment,those in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:Ilaprazole sodium in the treatment of the patients with peptic ulcer hemorrhage can improve the success rate of hemostasis,improve coagulation function indicators,and reduce the rebleeding rate,the incidence of adverse reactions.Moreover,it is superior to Esomeprazole Sodium treatment.