鼻渊通窍颗粒联合地氯雷他定治疗慢性鼻窦炎不合并息肉临床研究

Clinical Study on Biyuan Tongqiao Granules Combined with Desloratadine for Chronic Sinusitis Without Polyps

目的:观察鼻渊通窍颗粒联合地氯雷他定片治疗慢性鼻窦炎不合并息肉患者的临床疗效。方法:收治80例慢性鼻窦炎不合并息肉的患者,按随机数字表法分为对照组和观察组各40例。对照组给予地氯雷他定片治疗,观察组在对照组治疗方案的基础上加用鼻渊通窍颗粒治疗,2组均治疗30 d。比较2组临床疗效,鼻塞、头面部胀痛、黏浊涕、嗅觉减退症状评分,鼻窦CT Lund-Mackay及鼻内镜Lund-Kennedy评分,炎症因子白细胞介素(IL)-2、IL-6、IL-37水平。结果:临床疗效总有效率观察组90.0%,对照组67.5%,差异有统计学意义(P<0.05)。2组鼻塞、头面部胀痛、黏浊涕、嗅觉减退症状评分均较治疗前降低,差异均有统计学意义(P<0.05);观察组鼻塞、头面部胀痛、黏浊涕、嗅觉减退症状评分均低于对照组,差异均有统计学意义(P<0.05)。2组鼻窦CT Lund-Mackay及鼻内镜Lund-Kennedy评分均较治疗前降低,差异均有统计学意义(P<0.05);观察组鼻窦CT Lund-Mackay评分及鼻内镜Lund-Kennedy评分均高于对照组,差异均有统计学意义(P<0.05)。2组血清IL-2、IL-6表达水平均较治疗前降低,IL-37水平均升高,差异均有统计学意义(P<0.05);观察组血清IL-2、IL-6、IL-37水平分别与对照组比较,差异均有统计学意义(P<0.05),观察组优于对照组。结论:鼻渊通窍颗粒联合地氯雷他定片可以调节IL-2、IL-6及IL-37表达水平,缓解慢性鼻窦炎不伴息肉患者临床症状,降低CT Lund-Mackay及鼻内镜Lund-Kennedy评分。

Objective:To observe the clinical effect of Biyuan Tongqiao Granules combined with Desloratadine Tablets on chronic sinusitis without polyps.Methods:A total of 80 cases of patients with chronic sinusitis without polyps were divided into the control group and the observation group according to the random number table method,with 40 cases in each group.The control group was treated with Desloratadine Tablets,and the observation group was additionally treated with Biyuan Tongqiao Granules based on the treatment plan of the control group.Both groups were treated for 30 days.The clinical effects,the scores of symptoms like nasal congestion,distending pain in head and face,mucous nose and hyposmia,the scores of sinus CT Lund-Mackay and nasal endoscopic Lund-Kennedy,and the levels of inflammatory factors including interleukin(IL)-2,IL-6 and IL-37 were compared between the two groups.Results:The total effective rate of clinical effect was 90.0%in the observation group,and 67.5%in the control group,the difference being significant(P<0.05).Symptom scores of nasal congestion,distending pain in head and face,mucous nose and hyposmia in the two groups were decreased when compared with those before treatment,differences being significant(P<0.05);the symptom scores of nasal congestion,distending pain in head and face,mucous nose and hyposmia in the observation group were lower than those in the control group,differences being significant(P<0.05).The scores of sinus CT Lund-Mackay and nasal endoscopic Lund-Kennedy in the two groups were decreased when compared with those before treatment,differences being significant(P<0.05).The scores of sinus CT Lund-Mackay and nasal endoscopic Lund-Kennedy in the observation group were higher than those in the control group,differences being significant(P<0.05).The expression levels of IL-2 and IL-6 in serum in the two groups were reduced when compared with those before treatment,and the levels of IL-37 were increased,differences being significant(P<0.05);the levels of IL-2,IL-6,and IL-37 in serum in the observation group were significantly different compared to those in the control group(P<0.05),with the observation group showing better results than the control group.Conclusion:Biyuan Tongqiao Granules combined with Desloratadine Tablets can regulate the expression levels of IL-2,IL-6 and IL-37,relieve the clinical symptoms of patients with chronic sinusitis without polyps,and reduce the scores of CT Lund-Mackay and nasal endoscopic Lund-Kennedy.