针刺联合作业疗法治疗精神分裂症疗效观察及对社会功能的影响

Clinical Effect of Acupuncture Combined with Occupational Therapy for Schizophrenia and Its Effects on Social Function

目的:观察针刺联合作业疗法治疗精神分裂症的临床疗效及对社会功能的影响。方法:将80例精神分裂患者按随机数字表法分为观察组和对照组各40例。2组均给予氯氮平片治疗。对照组在氯氮平片基础上予以作业疗法治疗,观察组在对照组基础上加用针刺治疗,2组均治疗6周。比较2组临床疗效、简明精神病评定量表(BPRS)评分、神经递质及个人和社会功能量表(PSP)评分。结果:治疗6周后,观察组总有效率92.50%,高于对照组75.00%,差异有统计学意义(P<0.05)。2组BPRS评分均较治疗前降低,观察组BPRS评分低于对照组,差异均有统计学意义(P<0.05)。2组血清γ-氨基丁酸(GABA)、5-羟色胺(5-HT)、多巴胺(DA)水平均较治疗前升高,观察组血清GABA、5-HT、DA水平均高于对照组,差异均有统计学意义(P<0.05)。2组PSP评分均较治疗前升高,观察组PSP评分高于对照组,差异均有统计学意义(P<0.05)。结论:针刺联合作业疗法治疗精神分裂症可改善临床症状、提高个人能力,帮助患者尽快回归社会,其作用机制可能与提高血清神经递质水平有关。

Objective:To observe the clinical effect of acupuncture combined with occupational therapy on schizophrenia and its effects on social function.Methods:A total of 80 cases of patients with schizophrenia were divided into the observation group and the control group according to the random number table method,with 40 cases in each group.The two groups were treated with Clozapine Tablets.The control group was additionally treated with occupational therapy based on Clozapine Tablets,and the observation group was additionally treated with acupuncture based on the treatment of the control group.Both groups were treated for six weeks.Clinical effects,Brief Psychiatric Rating Scale(BPRS)scores,neurotransmitter,and Personal and Social Function Scale(PSP)scores were compared between the two groups.Results:After six-week treatment,the total effective rate was 92.50%in the observation group,which was higher than that of 75.00%in the control group,difference being significant(P<0.05).The scores of BPRS in the two groups were decreased when compared with those before treatment,and the BPRS scores in the observation group were lower than those in the control group,differences being significant(P<0.05).The levels ofγ-aminobutyric acid(GABA),5-hydroxytryptamine(5-HT),and dopamine(DA)in serum in the two groups were increased when compared with those before treatment,and the levels of GABA,5-HT,and DA in the observation group were higher than those in the control group,differences being significant(P<0.05).The scores of PSP in the two groups were enhanced when compared with those before treatment,and the PSP scores in the observation group were higher than those in the control group,differences being significant(P<0.05).Conclusion:Acupuncture combined with occupational therapy for schizophrenia can,improve clinical symptoms,enhance personal abilities,and help patients return to society as soon as possible.Its mechanism of action may be related to increasing serum neurotransmitter levels.