冠心病中医证素分布及与危险因素的相关性研究

Study on the Distribution of Traditional Chinese Medical Syndrome Elements and Their Correlation with Risk Factors in Patients with Coronary Heart Disease

目的 研究冠状动脉粥样硬化性心脏病(简称“冠心病”)患者的中医证素分布及其与危险因素的相关性。方法 纳入冠心病患者473例,综合中医四诊资料进行辨证;利用Logistic回归分析检测中医证素和危险因素的相关性。结果 473例冠心病患者中包含8种中医证素,所占比例由多到少依次为血瘀、热毒、痰浊、气虚、阴虚、气滞、阳虚、寒凝。中医证素和危险因素的相关性分析显示,男性是热毒证的危险因素,女性、年龄是其保护因素;血脂异常史是血瘀证的危险因素;女性、年龄、家族史是气虚证的危险因素;年龄是阴虚证的危险因素。结论 危险因素与冠心病患者中医证素存在一定相关性,性别与热毒证、气虚证相关,年龄与热毒证、气虚证、阴虚证相关,血脂异常与血瘀证相关,家族史与气虚证相关。

Objective To study the distribution of TCM syndrome elements in patients with coronary heart disease and its correlation with risk factors.Methods A total of 473 patients with coronary heart disease were enrolled,and the syndrome differentiation was car-ried out based on the four diagnostic data of traditional Chinese medicine.Results A total of 473 patients with coronary heart disease were included in the study.Logistic regression analysis was used to detect the correlation between TCM syndrome elements and risk factors.Methods A total of 473 patients with coronary heart disease included 8 kinds of TCM syndrome elements,the proportion of which was blood stasis,heat toxin,phlegm turbidity,qi deficiency,yin deficiency,qi stagnation,yang deficiency,and cold coagulation.Men are the risk factors of heat-toxic syndrome,while women and age are the protective factors of heat-toxic syndrome.The history of dyslipidemia is the risk factor of blood stasis syndrome.Women,age and family history are the risk factors of qi deficiency syndrome,while age is the risk factor of yin deficiency syndrome.Conclusion There is a certain correlation between the risk factors and the syn-drome elements of TCM in patients with coronary heart disease.Gender is related to heat toxin syndrome and qi deficiency syndrome,age is related to heat toxin syndrome,qi deficiency syndrome and yin deficiency syndrome,abnormal blood lipids is related to blood stasis syndrome,and family history is related to qi deficiency syndrome.