阿托伐他汀钙片、阿司匹林肠溶片与胞磷胆碱片联合治疗脑梗死的临床疗效及对总胆固醇水平的影响

Clinical Efficacy of Atorvastatin Calcium Tablets,Aspirin Enteric-coated Tablets Combined with Citicoline Tablets in the Treatment of Cerebral Infarction and its Effect on Total Cholesterol Level

目的研究阿托伐他汀钙片(AC)、阿司匹林肠溶片(ASA)联合胞磷胆碱片治疗脑梗死的临床疗效及对总胆固醇水平的影响。方法纳入2020年6月-2023年6月龙南市第一人民医院收治的60例脑梗死患者,行随机数字表法分为对照组(30例)与观察组(30例),对照组给予AC+ASA治疗,观察组在其基础上联合胞磷胆碱片治疗,比较两组临床疗效、美国国立卫生研究院卒中量表评分(NIHSS)、改良Barthel指数(MBI)、血脂水平[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)]、不良反应、复发情况。结果观察组治疗优良率(90.00%)高于对照组(66.67%)(P<0.05);两组治疗后NIHSS分数下降,MBI分数升高,且观察组NIHSS分数低于对照组,MBI分数高于对照组(P<0.05);两组治疗后TC、TG、LDL-C指标降低,HDL-C指标升高,且观察组TC、TG、LDL-C指标低于对照组,HDL-C指标高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组复发率低于对照组(P<0.05)。结论AC、ASA与胞磷胆碱片联合应用可提高脑梗死治疗效果,改善患者神经功能,调节其总胆固醇等血脂水平,降低复发风险,且具有较高用药安全性。

Objective To study the clinical efficacy of atorvastatin calcium tablets(AC),aspirin enteric-coated tablets(ASA)combined with citicoline tablets in the treatment of cerebral infarction and its effect on total cholesterol level.Methods Sixty patients with cerebral infarction admitted to Longnan First People's Hospital from June 2020 to June 2023 were randomly divided into control group(30 patients)and observation group(30 patients).The control group was treated with AC+ASA,and the observation group was treated with citicoline tablets on the basis of the control group.The clinical efficacy,National Institutes of Health Stroke Scale score(NIHSS),modified Barthel index(MBI),blood lipid levels[total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL-C),low density lipoprotein(LDL-C)],adverse reactions and recurrence were compared between the two groups.Results The excellent and good rate of treatment in the observation group(90.00%)was higher than that in the control group(66.67%)(P<0.05).After treatment,the NIHSS score of the two groups decreased and the MBI score increased,and the NIHSS score of the observation group was lower than that of the control group,and the MBI score was higher than that of the control group(P<0.05).After treatment,the TC,TG and LDL-C indexes of the two groups decreased,the HDL-C index increased,and the TC,TG and LDL-C indexes of the observation group were lower than those of the control group,the HDL-C index was higher than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The recurrence rate of the observation group was lower than that of the control group(P<0.05).Conclusion The combined application of AC,ASA and citicoline tablets can improve the therapeutic effect dor patients with cerebral infarction,improve the neurological function,regulate the blood lipid levels such as total cholesterol,reduce the risk of recurrence,and has high drug safety.