柏苦苓合剂治疗急性湿疹的临床观察

Clinical Observation of Baikuling Mixture in Treating Acute Eczema

目的 观察柏苦苓合剂治疗急性湿疹(湿热浸淫证)的临床疗效和安全性。方法 采用随机数字表法将患者127例分为西药组40例、中药组44例、联合组43例。西药组采用左西替利嗪片及硼酸外敷等治疗;中药组采用柏苦苓合剂治疗;联合组以上述两组的中、西药联合治疗。观察各组治疗前、治疗2周、随访时瘙痒程度、皮损面积、湿疹严重指数(EASI)评分、中医证候的评分变化和治疗期间的不良反应。结果 治疗2周时西药组、中药组、联合组患者瘙痒程度评分、皮损面积评分、中医证候评分均较治疗前明显下降(P <0.05)。随访时联合组的各项评分优于中药组和西药组(P <0.05)。此外西药组的复发率为40.63%,高于其他两组(P <0.05)。结论 柏苦苓合剂治疗急性湿疹(湿热浸淫证)可明显减轻临床症状,较单纯西药治疗复发率低,且无不良反应。

Objective:To investigate the clinical efficacy and safety of Baikuling mixture in the treatment of acute eczema(syndrome of dampness-heat infiltration).Methods:Using the random number table method,127 pa-tients were divided into three groups:the western medicine group(40 cases),the TCM group(44 cases),and the combined group(43 cases).The western medicine group was treated with levocetirizine tablets and topical borax;the TCM group was treated with Baikuling mixture;the combined group received both western and TCM.The changes in itching severity,lesion area,Eczema Area and Severity Index(EASI)scores,and TCM syndrome scores were observed before treatment,after 2 weeks of treatment,and during follow-up.Adverse reactions during treat-ment were also recorded.Results:After 2 weeks of treatment,the itching severity scores,lesion area scores,and TCM syndrome scores of the western medicine group,the TCM group,and the combined group all significantly de-creased compared with before treatment(P<0.05).During follow-up,the combined group′s scores were better than those of the TCM group and the western medicine group(P<0.05).Additionally,the recurrence rate in the western medicine group was 40.63%,which was higher than that of the other two groups(P<0.05).Conclusion:Baikuling mixture can significantly alleviate clinical symptoms in patients with acute eczema(syndrome of damp-ness-heat infiltration),has a lower recurrence rate compared with monotherapy with western medicine,and has no adverse reactions.