抗菌肽免疫调控作用及其在自身免疫性疾病应用研究进展

Research progress on the immunomodulatory effect of antimicrobial peptides and their application in autoimmune diseases

目的自身免疫性疾病是机体免疫系统对自身成分发生免疫应答而引起器官功能紊乱的一类疾病,难以彻底治愈,给患者造成巨大痛苦。抗菌肽是先天免疫系统的重要效应分子,可以通过多种免疫调节作用刺激或增强机体免疫反应,因而在自身免疫性疾病的治疗研究中被广泛关注。在自身免疫性疾病中,抗菌肽不仅对Ⅰ型糖尿病、类风湿性关节炎具有很好的治疗作用,还用于系统性红斑狼疮、银屑病、干燥综合征、系统性硬化症的治疗,并表现出良好的应用前景。探讨抗菌肽的免疫调控活性及其在自身免疫性疾病治疗中的研究进展,可以为抗菌肽免疫调控作用机制的深入研究提供文献支持,为抗菌肽今后在自身免疫性疾病临床应用上提供理论参考。

Objective Autoimmune diseases are a kind of diseases inducing organ dysfunction caused by the immune response to its own components.They are difficult to be completely cured and cause great trouble to patients.Antimicrobial peptides are important effector molecules of the innate immune system,which can stimulate or enhance the immune response through a variety of immune regulatory effects,so they have been widely concerned in the treatment of autoimmune diseases.In autoimmune diseases,antimicrobial peptides not only have a good inhibitory effect on the course of type I diabetes and rheumatoid arthritis,but also participate in the treatment of systemic lupus erythematosus,psoriasis,Sjogren’s syndrome and systemic sclerosis,which all show a good application prospect.Exploring the immune regulatory activity of antimicrobial peptides and its research progress in the treatment of autoimmune diseases can provide literature support for the in-depth study of the immune regulatory mechanism of antimicrobial peptides and provide theoretical reference for the application of antimicrobial peptides in the clinical treatment of autoimmune diseases in the future.