摘要
Cervical intraepithelial neoplasia grade 2(CIN2)lesions may regress spontaneously,offering an alternative to immediate treatment,especially for women of childbearing age(15–45 years).We conducted a prospective multicentre study on conservative CIN2 management,with semiannual follow-up visits over 24 months,biomarkers’investigation and treatment for progression to CIN3+or CIN2 persistence for more than 12 months.Here,we assess women’s willingness to participate and adherence to the study protocol.The study was set in population-based organised cervical cancer screening.From April 2019 to October 2021,640 CIN2 cases were diagnosed in women aged 25–64 participating in the screening programmes.According to our predefined inclusion and exclusion criteria,228(35.6%)women were not eligible;93(22.6%)of the 412 eligible refused,and 319(77.4%)were enrolled.Refusal for personal reasons(ie,desire to become pregnant,anxiety,difficulty in complying with the study protocol)and external barriers(ie,residence elsewhere and language problems)accounted for 71%and 17%,respectively.Only 9%expressed a preference for treatment.The primary ineligibility factor was the upper age limit of 45 years.After enrolment,12(4%)women without evidence of progression requested treatment,125(39%)were lost to follow-up(mostly after 6–12 months)and 182(57%)remained compliant.Remarkably,40%of enrolees did not fully adhere to the protocol,whereas only 5%(20/412)of the eligible women desired treatment.Our study demonstrates a good acceptance of conservative management for CIN2 lesions by the women,supporting its implementation within cervical screening programmes.
基金
funded by the Veneto Region(grant number RSFR-2017-00000523),and covers also the publication costs.
