基于铁死亡探讨中医药干预肾脏疾病作用机制研究进展

Research progress on mechanism of traditional Chinese medicine in intervention of kidney disease based on ferroptosis

肾脏是维持人体内环境稳态的首要排泄器官,复杂的微环境和精密的调控机制是造成肾脏结构和功能障碍的根本原因。铁死亡是由Fe^(2+)超载、氨基酸代谢失常、脂质过氧化物累积诱发的新型程序性细胞死亡。中医药在治疗肾脏疾病方面有着独特的理论和丰硕的临床经验,大量研究表明中医药通过调节肾内细胞铁死亡有助于改善肾脏病理损害、延缓肾病病程进展,应用前景广阔。基于铁死亡角度,从机制上探讨中医药干预肾脏疾病病程进展的最新研究成果,为临床防治肾脏疾病提供新的机制参考和思路启发。

The kidney is the prime excretory organ for maintaining environmental homeostasis in the human body,and complex microenvironment and sophisticated regulatory mechanisms are the fundamental causes of renal structural and functional dysfunction.Ferroptosis is a new type of programmed cell death induced by Fe^(2+)overload,abnormal metabolism of amino acids,and accumulation of lipid peroxides.Traditional Chinese medicine(TCM)has a unique theory and fruitful clinical experience in treating kidney diseases,and a large number of studies have shown that TCM can help alleviate kidney pathological damage and delay the progression of nephropathies by regulating intrarenal cell ferroptosis,which has a very broad application prospect.Based on the perspective of ferroptosis,the latest research results of TCM intervention in the progression of renal diseases from the perspective of mechanism can provide new mechanism reference and inspiration for the clinical prevention and treatment of kidney diseases.