喉癌患者预后相关因素分析

Analysis of Related Factors Affecting Prognosis of Laryngeal Cancer Patients

目的分析喉癌患者的临床特点及其对预后的影响,为喉癌患者治疗方案的选择及预后的判断提供依据。方法选取2011年1月至2017年12月在宁夏医科大学总医院住院并接受治疗的222例喉癌患者为研究对象,收集患者一般情况、病理分期、临床分期、手术方式、综合治疗生存情况等,用Kaplan-Meier法及Cox回归模型进行生存分析。结果222例喉癌患者第1、3、5、7年的生存率分别为93.1%、84.8%、70.4%、63.6%。不同年龄、临床分期及手术方式喉癌患者的生存率差异均有统计学意义(P均<0.05)。Cox回归模型分析显示,对生存有影响的因素包括年龄(RR=3.448,P<0.001)和临床分期(RR=0.302,P=0.004)。结论年龄、临床分期对喉癌患者的生存预后有影响,在治疗中应依据多种因素进行综合评估并选择个性化治疗。

Objective To analyze the prognostic factors of laryngeal cancer,and to provide evidence for the selection and improvement of treatment and prognosis of laryngeal cancer patients.Methods 222 cases of laryngeal cancer hospitalized and treated in General Hospital of Ningxia Medical University from January 2011 to December 2017 were confirmed by electronic laryngoscope,neck enhanced CT and pathological biopsy before surgery.Data were collected to record the patients general condition,pathological stage,clinical stage and surgical method.Kaplan-Meier method and Cox regression model were used for survival analysis.Results The 1,3,5 and 7-year survival rates of 222 patients with laryngeal cancer were 93.1%,84.8%,70.4%and 63.6%,respectively.There were statistically significant differences in survival rates among patients with laryngeal cancer of different ages,clinical stages,and surgical methods(P all<0.05).Cox regression model analysis showed that factors affected survival including age(RR=3.448,P<0.001)and clinical stage(RR=0.302,P=0.004).Conclusion Age and clinical staging have an impact on the survival prognosis of laryngeal cancer patients,and personalized treatment should be selected based on a comprehensive evaluation of multiple factors during treatment.