摘要
目的:了解老年抑郁症(late life depression,LLD)患者认知功能的影响因素。方法:选取伴有认知障碍的LLD患者118例,采用一般资料调查表、汉密尔顿抑郁量表17项(Hamilton depression scale 17 items,HAMD-17)及阿尔茨海默病评定量表-认知分量表(Alzheimer's disease assessment scale-cognitive section,ADAS-cog)调查伴有认知障碍的LLD患者的基本情况、抑郁症状及认知功能。采用分析方法,探讨对伴有认知障碍的LLD患者认知功能的影响因素。结果:单因素分析显示有吸烟史、有饮酒史、有家族史、抑郁发作次数增加、既往无抽搐电休克治疗(modified electroconvulsive therapy,MECT)次数增加、收缩压升高、体质量指数(body mass index,BMI)升高均能增加ADAS-cog的分值。多元线性回归分析显示有吸烟史、有饮酒史、有精神疾病家族史、抑郁发作次数增加、HAMD-17数值升高、BMI数值升高、收缩压升高均能增加ADAS-cog的分值,偏回归系数(β)均>0。结论:抑郁症的发作次数、抑郁症状严重程度、血压值、BMI及吸烟饮酒史均是老年抑郁症患者认知功能障碍的独立危险因素。
Objective:To understand the influencing factors of cognitive function in patients with late life depression(LLD).Method:A total of 118 LLD patients with cognitive impairment were selected,and their basic information,depressive symptoms,and cognitive function were investigated using the general information survey,Hamilton depression scale 17 items(HAMD-17),and Alzheimer's disease assessment scale cognitive section(ADAS-cog).The influencing factors of cognitive function in LLD patients with cognitive impairment were explored by analysis methods.Results:Univariate analysis showed that a history of smoking,alcohol consumption,family history,increased frequency of depressive episodes,increased frequency of modified electroconvulsive therapy(MECT),elevated systolic blood pressure,and elevated body mass index(BMI)all increased ADAS-cog scores.Multiple linear regression analysis showed that having a history of smoking,drinking,family history of mental illness,increased frequency of depressive episodes,elevated HAMD-17 values,elevated BMI values,and elevated systolic blood pressure all increased ADAS-cog scores,with all partial regression coefficients(β)>0.Conclusion:The frequency of depressive episodes,severity of depressive symptoms,blood pressure,BMI,and smoking and drinking history are all independent risk factors for cognitive function in LLD with cognitive impairment.
作者
汪晓
王艺达
周娇娇
朱柯蒙
马向林
张庆娥
WANG Xiao;WANG Yi-da;ZHOU Jiao-jiao;ZHU Ke-meng;MA Xiang-lin;ZHANG Qing-e(Beijing Anding Hospital,Capital Medical University,The National Clinical Research Center for Mental Disorders,Beijing Key Laboratory of Mental Disorders,Department of Psychiatry,Capital Medical University,Beijing 100088,China)
出处
《临床精神医学杂志》
CAS
2024年第5期337-340,共4页
Journal of Clinical Psychiatry
基金
首都卫生发展科研专项基金(首发2022-3-2124)
高层次公共卫生技术人才建设项目培养计划(学科骨干-02-38)
中央保健科研一般项目(2022YB68)。
关键词
老年抑郁症
认知障碍
影响因素
late life depression
cognitive impairment
influencing factors