人费克蓝姆菌引起面部痈1例病例报道

A Study of Clinical Characteristics of Infection by Facklamia Hominis

目的分析人费克蓝姆菌感染的临床特点,避免实验室漏检和临床误诊,从而助力临床精准诊疗。方法回顾分析本院1例由人费克蓝姆菌引起面部痈的患者的临床资料,同时以“Facklamia hominis”为关键词在PubMed和Medline上检索2013~2023年英文文献;以“人费克蓝姆菌”为关键词在万方数据库、中国期刊网全文数据库检索2013~2023年中文文献。结果本院1例为人费克蓝姆菌引起老年糖尿病患者左侧面部痈,经实验室准确鉴定且与临床有效沟通后,最终采用清创和局部用药方式,同时用激光辅助治疗,患者皮肤脓肿治愈。文献复习共纳入10篇文献,10例人费克蓝姆菌感染患者,男5例,女5例,年龄中位数63.5岁;患者多伴有基础疾病或手术史(9/10),可引起不同器官和部位的感染,包括心脏、胸部、泌尿道、肾脏、中枢神经系统、肩胛骨、脊柱、包皮、皮肤表面和假体。临床表现不具特征性,不同感染部位有不同的临床表现,部分病例会出现发热(3/10),接受头孢类抗菌药物治疗占40.0%(4/10),接受外科手术进行辅助治疗占50.0%(5/10),治愈率达90.0%(9/10)。结论结合病例和文献复习,人费克蓝姆菌是一种罕见病原体,其感染临床表现不具特征性,好发于有基础疾病患者,对多数抗菌药物敏感,结合有效的外科干预手段,可提高预后效果。

Objective The objective of the current study is to analyze the clinical characteristics of infections caused by Facklamia hominis,and to prevent laboratory missed detections and clinical misdiagnoses,thereby facilitating the accurate clinical diagnosis and treatment.Methods A retrospective analysis was conducted for clinical data of a patient with facial abscess caused by Facklamia hominis in the hospital.We retrieved previous literatures related to“Facklamia hominis”reported from 2013 to 2023 in PubMed,Medline,Wanfang databases,and the China Journal Network full-text databases.Results In this hospital,a case of carbuncle on the left side of the face in an elderly diabetic patient,caused by Facklamia hominis,was treated.After accurate laboratory identification and effective clinical communication,debridement and local medication were ultimately used,along with laser-assisted treatment.The patient’s skin abscess was then cured.In related literature review,10 articles were included,in which ten patients with Facklamia hominis infection were studied,including five males and five females,with a median age of 63.5 years;Patients frequently had underlying diseases or a history of surgery(90%);The infection could affect various organs and regions,including heart,chest,urinary tract,kidneys,central nervous system,scapula,spine,foreskin,skin,and prosthetics.The clinical presentations were nonspecific,differing by the infected sites.Some cases exhibited fever(30%);40.0%(4 out of 10)were treated with cephalosporin antibiotics,while 50.0%(5 out of 10)underwent surgical adjunct therapy,boasting a 90.0%(9 out of 10)cure rate.Conclusion Based on case studies and literature review,we show that Facklamia hominis is a rare pathogen.The clinical manifestations of Facklamia hominis infection are not characteristic,and it primarily affects patients with underlying diseases.It is sensitive to most antibiotics,and effective surgical interventions can improve the prognosis.