载脂蛋白CⅢ与相关疾病的研究进展

Research progress on apolipoprotein CⅢand related diseases

载脂蛋白是脂蛋白中的蛋白部分,目前已明确有五大种类(ApoA、ApoB、ApoC、ApoD、ApoE)。其中ApoC由于相对分子质量较小,很容易在高密度脂蛋白(HDL)和含载脂蛋白之间转移,是可交换的载脂蛋白,可以调节血浆三酰甘油(TG)和胆固醇(CHO)水平。ApoCⅢ作为ApoC家族中含量最丰富的载脂蛋白,在富含三酰甘油脂蛋白(TRL)的分解代谢中具有重要的调节作用,与多种疾病的发生密切相关,值得临床关注。该文从ApoCⅢ的结构和功能、与疾病的关系、发病机制以及药物使用研究等方面进行阐述。

Apolipoprotein is the protein part of lipoprotein,which has been clearly divided into five categories(ApoA,ApoB,ApoC,ApoD and ApoE).Due to its relatively small molecular weight,ApoC is easily transferred between high density lipoprotein(HDL)and apolipoproteins,and is an interchangeable apolipoprotein that could regulate plasma levels of triacylglycerol(TG)and cholesterol(CHO).As the most abundant apolipoprotein in the ApoC family,ApoCⅢplays an important regulatory role in the catabolism of triglyceride-rich lipoprotein(TRL),which is closely related to the occurrence of many diseases and deserves clinical attention.This article will discuss the structure and function of ApoCⅢ,its relationship with disease,pathogenesis and drug use.