母婴分离动物模型及其影响学习记忆相关机制的研究进展

Research progress in animal models of maternal separation and related mechanisms that affect learning and memory

母婴分离(maternal separation,MS)是一种生命早期的社会剥夺,会损伤啮齿类动物(主要为大鼠或小鼠)成年后学习记忆能力。MS动物模型是目前研究学习记忆能力障碍表现及其机制的常用动物模型之一。本文对MS动物模型以及MS影响子代学习记忆的相关机制进行综述,旨在为后续进行MS子代学习记忆的相关研究提供依据。

Maternal separation is a kind of social deprivation in early life that has been shown to impede the learning and memory abilities of rodents(mainly rats or mice)in adulthood.Animal models of mother-infant separation are commonly used to study the manifestations and mechanisms of learning and memory impairment.In this paper,an animal model of maternal-infant separation and related mechanisms of maternal-infant separation that affect offspring’s learning and memory are reviewed to provide a basis for subsequent research on maternal-infant separation.