维生素D在非酒精性脂肪性肝病中的作用

Role of vitamin D in non-alcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)是全世界常见慢性肝病之一。NAFLD的分子机制复杂,涉及许多信号分子,维生素D(VD)/维生素D结合蛋白(VDBP)/维生素D受体(VDR)轴也参与其中。VD是一种脂溶性类固醇,其能参与调节脂质代谢、胰岛素分泌、免疫功能、炎症反应等生物过程。研究表明,VD缺乏与肝脏脂质积累、炎症、胰岛素抵抗、氧化应激、肠道菌群失调、自噬、凋亡、焦亡以及纤维化关系密切,在NAFLD的发生发展中发挥着重要作用。本文综述了近年来VD在NAFLD领域中的研究进展,包括VD的生理学特征及其在NAFLD中的作用机制,以期为防治NAFLD提供参考。

Non-alcoholic fatty liver disease(NAFLD)is one of the common chronic liver diseases in the world.The molecular mechanism of NAFLD is complex,involving many signal molecules,and the vitamin D(VD)/VDBP/vitamin D receptor(VDR)axis is also involved.VD is a lipid-soluble steroid,which can participate in the regulation of lipid metabolism,insulin secretion,immune function,inflammatory response and other biological processes.Studies have shown that VD deficiency is closely related to liver lipid accumulation,inflammation,insulin resistance,oxidative stress,intestinal flora imbalance,autophagy,apoptosis,pyroptosis and fibrosis,and plays an important role in the occurrence and development of NAFLD.This paper reviews the research progress on Vitamin D in recent years in the field of NAFLD,including the physiological characteristics of VD and its role in the NAFLD mechanism,so as to provide references for the prevention and treatment of NAFLD.