活泼瘤胃球菌在炎症性肠病发病中的作用

Role of Ruminococcus gnavus in the pathogenesis of inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)是一种病因尚未阐明的慢性非特异性肠道炎症性疾病。发病机制可以概括为环境因素作用于遗传易感者,在肠道微生物的参与下,肠道免疫失衡,肠黏膜屏障受损,导致肠黏膜持续炎症损伤。肠道菌群与IBD的发生发展密切相关,其中活泼瘤胃球菌作为人类肠道中最丰富的共生菌之一,在IBD患者肠道中富集,其与IBD的关系受到关注。本文针对活泼瘤胃球菌的特性、在肠道中的定殖及在IBD发病中的相关机制等做一综述,以期为IBD发病机制、治疗措施的研究提供新的思路。

Inflammatory bowel disease(IBD)is a chronic non-specific intestinal inflammatory disease whose etiology has not been elucidated.The pathogenesis can be summarized as environmental factors acting on genetically susceptible individuals,with the participation of intestinal microorganisms,the imbalance of intestinal immune and damage to the intestinal mucosal barrier,resulting in persistent inflammatory damage to the intestinal mucosa.Gut microbiota is closely related to the development and progression of IBD.Ruminococcus gnavus,as one of the most abundant symbiotic bacteria in the human gut,has been shown to be enriched in IBD and is associated with IBD.This review focuses on the characteristics of Ruminococcus gnavus,its colonization in the intestinal tract and its role in the pathogenesis of IBD,so as to provide new ideas for the study of the pathogenesis and treatment of IBD.