大孔结构水凝胶支架的研究进展

Research progress on macroporous hydrogel scaffolds

水凝胶作为一种组织工程修复材料,具有良好的生物相容性、可降解性及可塑性,由于缺乏合适的孔隙特征,限制了凝胶内外细胞的增殖、迁移及血管再生,严重影响组织修复效果,因而水凝胶大孔结构的制备成为研究热点。本文就孔隙特征对支架生物学行为的具体影响及近年来水凝胶大孔结构的制备方法作一综述。

As a tissue engineering restorative material,hydrogel possesses outstanding biocompatibility,degradability and plasticity.Due to the lack of appropriate pore characteristics,the proliferation,migration and angiogenesis of cells inside and outside the gel are limited,which seriously affect the results of tissue engineering.Therefore,the preparation of macroporous structure has become a research focus on modification of hydrogel.In this paper,the effect of pore characteristics on biological behavior of scaffolds and the prepared methods of macroporous structure in recent years are reviewed.