乙肝病毒载量与妊娠期并发症间的关系分析

Analysis of the relationship between HBV viralload and complications during pregnancy

目的 探讨乙肝病毒载量与妊娠期并发症间的关系。方法 本研究纳入2020年12月至2022年12月间就诊于广东省妇幼保健院的1595例符合标准的乙肝孕妇作为研究对象,采用100000IU/ml为截断值,HBV-DNA定量≥100000IU/ml的孕妇为高病毒定量组,HBV-DNA定量<100000IU/ml者为低病毒定量组,分析高病毒组及低病毒组两组孕妇妊娠期常见母胎并发症发生情况。结果 高病毒定量组发生胎儿窘迫的风险显著高于低病毒定量组(P<0.05),而两组间妊娠期高血压疾病、妊娠期糖尿病、妊娠期肝内胆汁淤积症、妊娠期贫血、产后出血、羊水量异常、前置胎盘、胎膜早破、早产无显著性差异(P>0.05)。结论 乙肝病毒高载量孕妇发生胎儿窘迫风险增加,应重视这部分人群的孕期阻断治疗。

Objective To investigate the relationship between HBV viral load and pregnancy complications.Methods 1595 pregnant women with hepatitis B who met the criteria were enrolled in the study.100000IU/ml was used as the cut-off value,and pregnant women with HBV-DNA quantification greater than or equal to 100000IU/ml were regarded as the high-virus-quantification group,while those with HBV-DNA quantification less than 100000IU/ml were regarded as the low-virus-quantification group,and common complications of pregnancy were analyzed in the two groups.Results The risk of fetal distress was significantly higher in the high-viral-quantification group than in the low-viral-quantification group(P<0.05),whereas there was no significant difference between the two groups in hypertensive disorder complicating pregnancy,diabetes mellitus of pregnancy,intrahepatic cholestasis of pregnancy,anemia of pregnancy,postpartum hemorrhage,abnormal amniotic fluid,placenta praevia,premature rupture of membranes,and preterm delivery(P>0.05).Conclusions Pregnant women with high HBV load have an increased risk of fetal distress,and attention should be paid to blocking treatment during pregnancy in this population.