丁苯酞联合依达拉奉治疗急性脑梗死的临床疗效及对血清中枢神经特异蛋白的影响

Clinical Efficacy of Butylphthalein combined with Edaravone in the Treatment of Acute Cerebral Infarction and Its Influence on Serum S100-β

目的 探讨丁苯酞联合依达拉奉治疗急性脑梗死的临床疗效及对血清中枢神经特异蛋白(S100-β)的影响。方法 选取2020年1月至2022年1月济宁市兖州区人民医院收治的120例急性脑梗死患者为研究对象,以抽签法随机分为观察组与对照组,各60例。对照组采用依达拉奉注射液治疗,观察组在对照组基础上联合丁苯酞注射液治疗。比较两组临床疗效、血清因子及神经、认知功能。结果 观察组治疗有效率为96.67%,高于对照组的83.33%,差异有统计学意义(P<0.05);治疗前两组血清神经元特异性烯醇化酶(NSE)、同型半胱氨酸(Hcy)及S100-β水平比较差异无统计学意义(P>0.05);治疗后两组血清NSE、Hcy及S100-β水平降低,且观察组低于对照组,差异有统计学意义(P<0.05);治疗前两组美国国立卫生研究院卒中量表(NIHSS)及简易智能精神状态检查量表(MMSE)评分比较差异无统计学意义(P>0.05);治疗后,两组NIHSS评分降低,且观察组低于对照组,两组MMSE评分升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论 对急性脑梗死患者联合应用丁苯酞与依达拉奉能显著提高临床治疗效果,有效改善神经、认知功能。

Objective To explore the clinical efficacy of butylphthalein combined with Edaravone in the treatment of acute cerebral infarction and the effect on serum S100-β.Methods A total of 120 patients with acute cerebral infarction admitted to Yanzhou District People's Hospital of Jining City from January 2020 to January 2022 were selected as the study objects and randomly divided into observation group and control group by drawing lots,with 60 cases in each group.The control group was treated with Edaravone injection,and the observation group was treated with butylphthalein injection on the basis of the control group.The clinical efficacy,serum factors and neurological and cognitive functions of the two groups were compared.Results The effective rate of the observation group was 96.67%,higher than that of the control group 83.33%,the difference was statistically significant(P<0.05).There were no significant differences in serum levels of neuron-specific enolase(NSE),homocysteine(Hcy)and S100-βbetween the two groups before treatment(P>0.05).After treatment,the serum levels of NSE,Hcy and S100-βin two groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).There was no significant difference in the scores of National Institutes of Health Stroke Scale(NIHSS)and Simple Intelligent Mental State Examination Scale(MMSE)between the two groups before treatment(P>0.05).After treatment,NIHSS score of the two groups was decreased,and the observation group was lower than the control group;MMSE score of the two groups was increased,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).Conclusion The combination of butylphthalein and edaravone in patients with acute cerebral infarction can significantly improve the clinical therapeutic effect,and promote the recovery of neurological and cognitive functions.